The aim of this study was to investigate gut inflammation and permeability in rats after duodenal-jejunal bypass (DJB) and in rats injected with a glucagon-like peptide-1 (GLP-1) receptor analog.
Twelve male 16-week-old obese diabetic rats were divided into three groups: the DJB group, the sham group, and the group injected daily with a GLP-1 receptor agonist (liraglutide). Gut inflammation and the expression of tight junction protein (claudin-1) were analyzed in the three groups at 8 weeks after surgery.
The DJB group showed significantly lower levels of gut inflammatory cytokines than the liraglutide group. Claudin-1 showed stronger intensity on immunofluorescent staining in the DJB group than that in the liraglutide group.
In summary, DJB surgery might maintain gut permeability via suppression of gut inflammation.
Gut inflammation Gut permeability Tight junction protein (claudin-1) GLP-1 receptor agonist (liraglutide) Gut inflammatory cytokines (IFN-γ, IL-1, IL-6, and TNF-α) Roux-en-Y reconstruction Bariatric surgery
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Compliance with Ethical Standards
All applicable institutional and/or national guidelines for the care and use of animals were followed. Informed consent statement does not apply to this study.
Conflict of Interest
The authors declare that they have no conflict of interest.
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