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A Pilot, Randomized Study in Women of Nutrition-Related Clinical Chemistry at 6 Weeks after Roux en Y Gastric Bypass: Comparison of Two Nutrition Support Plans

  • Robert A. DiSilvestroEmail author
  • Patricia Choban
  • Fernando N. Aguila
  • Marcus Miller
  • Elizabeth Joseph
Original Contributions
  • 39 Downloads

Abstract

Background

The current pilot study tested a twofold hypothesis: some nutrition-related chemical measures change by 6 weeks after Roux en Y Gastric Bypass (RNYGB); one of two nutrition support plans will prevent chemical signs of nutrition problems at 6 weeks better than the other. After RNYGB, nutrition support should begin right away. However, studies on nutritional status mostly examine subjects much later. In addition, little attention has been paid to optimizing nutrition support plans.

Methods

Premenopausal females scheduled for RNYGB were given either a commercially available meal replacement product (2 servings/day) + other supplements or just a new meal replacement (2 servings/day). The latter included some nutrient versions that might enhance absorption. Blood and urine samples were taken before and 6 weeks after surgery.

Results

In both groups, plasma vitamin D and B12 did not change, plasma osteopontin and vascular endothelial growth factor rose, while plasma retinol binding protein and a bone resorption marker declined. Copper status changes differed between groups based on plasma ceruloplasmin. Iron status improved in both groups (ferritin to c-reactive protein ratios). With the new formulation, magnesium status may have improved, urinary potassium rose, and blood sugar fell. In the other group, a liver damage marker increased, while homocysteine decreased.

Conclusions

Nutrition-related parameters showed varying trends 6 weeks after RNYGB. Some of the trends were affected by the type of nutritional support provided.

Keywords

Bariatric Gastric bypass Nutritional status Vitamins Minerals 

Notes

Acknowledgements

The authors thank Shella Walker for help with logistics and interactions with the subjects. This research was supported partly by a loan and a small grant from Braintree Business Development Center, Mansfield, OH.

Compliance with Ethical Standards

The protocol was approved by the xxx Human Subjects Biomedical Institutional Review Board.

Conflict of Interest

All but one author declare no conflict of interest. Robert DiSilvestro is president of Medinutra LLC, a company that after the study, has been developing a commercial product that overlaps the new product tested in this study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Medinutra LLCDublinUSA
  2. 2.Department of SurgeryCentral Ohio Surgical Associates, Mt Carmel Health CenterColumbusUSA

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