A Pilot, Randomized Study in Women of Nutrition-Related Clinical Chemistry at 6 Weeks after Roux en Y Gastric Bypass: Comparison of Two Nutrition Support Plans
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The current pilot study tested a twofold hypothesis: some nutrition-related chemical measures change by 6 weeks after Roux en Y Gastric Bypass (RNYGB); one of two nutrition support plans will prevent chemical signs of nutrition problems at 6 weeks better than the other. After RNYGB, nutrition support should begin right away. However, studies on nutritional status mostly examine subjects much later. In addition, little attention has been paid to optimizing nutrition support plans.
Premenopausal females scheduled for RNYGB were given either a commercially available meal replacement product (2 servings/day) + other supplements or just a new meal replacement (2 servings/day). The latter included some nutrient versions that might enhance absorption. Blood and urine samples were taken before and 6 weeks after surgery.
In both groups, plasma vitamin D and B12 did not change, plasma osteopontin and vascular endothelial growth factor rose, while plasma retinol binding protein and a bone resorption marker declined. Copper status changes differed between groups based on plasma ceruloplasmin. Iron status improved in both groups (ferritin to c-reactive protein ratios). With the new formulation, magnesium status may have improved, urinary potassium rose, and blood sugar fell. In the other group, a liver damage marker increased, while homocysteine decreased.
Nutrition-related parameters showed varying trends 6 weeks after RNYGB. Some of the trends were affected by the type of nutritional support provided.
KeywordsBariatric Gastric bypass Nutritional status Vitamins Minerals
The authors thank Shella Walker for help with logistics and interactions with the subjects. This research was supported partly by a loan and a small grant from Braintree Business Development Center, Mansfield, OH.
Compliance with Ethical Standards
The protocol was approved by the xxx Human Subjects Biomedical Institutional Review Board.
Conflict of Interest
All but one author declare no conflict of interest. Robert DiSilvestro is president of Medinutra LLC, a company that after the study, has been developing a commercial product that overlaps the new product tested in this study.
- 3.Peterson L. Bariatric surgery and vitamin D: key messages for surgeons and clinicians before and after bariatric surgery. Minerva Chir. 2016;71:322–36.Google Scholar
- 5.Wardlaw GM, Hampl JS, DiSilvestro RA. Perspectives in nutrition. 6th ed. New York: McGraw Hill; 2004.Google Scholar
- 6.Calvo MS, Eyre DR, Gunberg CM. Molecular basis and clinical application of biological markers of bone turnover. Endocrinol Rev. 1996;17:333–68.Google Scholar
- 13.Carrelli A, Bucovsky M, Horst R, et al. Vitamin D storage in adipose tissue of obese and normal weight women. J Bone Miner Res. 2016;32:217–42.Google Scholar
- 17.Pepys MB. The acute phase response and C-reactive protein. In: Weatherall DJ, Ledingham JGG, Warrell DA, editors. Oxford textbook of medicine. 2nd ed. Oxford: Oxford University Press; 1995. p. 1527–33.Google Scholar
- 30.DiSilvestro RA, Marten JT, Skehan M. Effects of copper supplementation on ceruloplasmin and copper-zinc superoxide dismutase activities in free-living rheumatoid arthritis patients. J Am Coll Nutr. 1992;11:177–80.Google Scholar
- 31.Bosanská L, Michalský D, Lacinová Z, et al. The influence of obesity and different fat depots on adipose tissue gene expression and protein levels of cell adhesion molecules. Physiol Res. 2010;59:79–88.Google Scholar
- 36.Martin H, Uring-Lambert B, Adrian M, et al. Effects of long-term dietary intake of magnesium on oxidative stress, apoptosis and ageing in rat liver. Magnes Res. 2008;21:124–30.Google Scholar