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Obesity Surgery

, Volume 29, Issue 7, pp 2045–2050 | Cite as

Lack of Improvement of Sperm Characteristics in Obese Males After Obesity Surgery Despite the Beneficial Changes Observed in Reproductive Hormones

  • Berniza Calderón
  • Lydia Huerta
  • Julio Galindo
  • José Manuel González Casbas
  • Héctor F. Escobar-Morreale
  • Antonia Martín-Hidalgo
  • José I. Botella-CarreteroEmail author
Original Contributions
  • 205 Downloads

Abstract

Background

Even though obesity surgery normalizes circulating testosterone concentrations in males with obesity-associated secondary hypogonadism, its impact on spermatogenesis remains controversial. We aimed to evaluate sperm characteristics in obese men after bariatric surgery as well as changes in reproductive hormones.

Methods

Twenty severely obese men (body mass index (BMI) ≥ 35 kg/m2) were evaluated before and 2 years after bariatric surgery. The serum was assayed for insulin, leptin, kisspeptin, and inhibin B, among other hormones. Homeostasis model assessment of insulin resistance (HOMA-IR) was estimated. We used World Health Organization reference values for sperm analysis.

Results

After surgery, serum total testosterone, calculated free testosterone, inhibin B, and kisspeptin increased, whereas fasting insulin, HOMA-IR, and leptin concentrations decreased. Despite these improvements, sperm volume showed a small decrease after surgery, while the rest of sperm characteristics remained mostly unchanged. Abnormal sperm concentration persisted in 60% of the patients.

Conclusions

Sperm characteristics may not improve after bariatric surgery despite the beneficial changes of reproductive hormones.

Keywords

Obesity Bariatric surgery Kisspeptin Leptin Semen analysis Male infertility 

Notes

Acknowledgments

We thank the nurses of the Department of Endocrinology and Nutrition for their help with the anthropometric measurements and blood sampling of the patients.

Funding

Supported by Grants PI18/00132, PI18/01122, and PI1600154 from Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness. Supported in part by the FondoEuropeo de Desarrollo Regional (FEDER) from the European Union. CIBERDEM and CIBEROBN are also initiatives of Instituto de Salud Carlos III. Dr. Calderón received a grant from MESCYT, Dominican Republic Ministry of Superior Education.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Written informed consent was obtained from all the participants included in the study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Berniza Calderón
    • 1
    • 2
  • Lydia Huerta
    • 3
    • 4
  • Julio Galindo
    • 5
  • José Manuel González Casbas
    • 6
    • 7
  • Héctor F. Escobar-Morreale
    • 1
    • 8
    • 9
  • Antonia Martín-Hidalgo
    • 3
    • 4
  • José I. Botella-Carretero
    • 1
    • 4
    • 9
    Email author
  1. 1.Department of Endocrinology and NutritionHospital Universitario Ramón y Cajal & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)MadridSpain
  2. 2.Instituto Tecnológico de Santo Domingo (INTEC)Santo DomingoDominican Republic
  3. 3.Department of Biochemistry-ResearchHospital Universitario Ramón y Cajal & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)MadridSpain
  4. 4.Centro de Investigación Biomédica en Red-Fisiopatología de Obesidad y Nutrición (CIBERobn)MadridSpain
  5. 5.Department of General and Digestive SurgeryHospital Universitario Ramón y Cajal & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)MadridSpain
  6. 6.Unit of Assisted ReproductionHospital Universitario Ramón y CajalMadridSpain
  7. 7.European Institute of FertilityMadridSpain
  8. 8.Centro de Investigación Biomédica en Red-Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)MadridSpain
  9. 9.University of Alcalá de Henares (UAH)MadridSpain

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