Obesity Surgery

, Volume 29, Issue 1, pp 311–315 | Cite as

Letter to the Editor: Circulating Adult Stem and Progenitor Cells After Roux-en-Y Gastric Bypass Surgery in Myotonic Dystrophy

  • Julia M. Kröpfl
  • Britta Wilms
  • Barbara Ernst
  • Bernd Schultes
  • Christina M. SpenglerEmail author
Letter to the Editor

In healthy subjects, homeostasis and repair of skeletal muscle rely on muscle-resident and circulating stem and progenitor cells, i.e., satellite cells and bone marrow–derived hematopoietic and endothelial (CPCs) or mesenchymal stem and progenitor cells (MPCs). Mature endothelial cells (ECs) support myogenesis by growth factor secretion [1]. Myotonic dystrophy type 1 (MD1) is a multisystem disorder of genetic origin that causes muscle wasting and impaired muscle regeneration. Furthermore, patients with MD1 are more prone to become adipose [2]. Muscle regeneration in obese MD1 patients by circulating precursor and supporting cells might be hampered since obesity suppresses the number and function of circulating precursor cells, as already shown for endothelial progenitor cells (EPCs) [3]. Weight loss management by bariatric surgery in obese patients without MD1 elevated the number of EPCs [4]. In MD1, however, bariatric surgery–induced CPC, MPC, and EC number increases could be...



The study was funded by the eSwiss Medical and Surgical Center in St. Gallen and ETH Zurich, Switzerland.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.


  1. 1.
    Stromberg A, Jansson M, Fischer H, et al. Bone marrow derived cells in adult skeletal muscle tissue in humans. Skelet Muscle. 2013;3(1):12.CrossRefGoogle Scholar
  2. 2.
    Llagostera E, Carmona MC, Vicente M, et al. High-fat diet induced adiposity and insulin resistance in mice lacking the myotonic dystrophy protein kinase. FEBS Lett. 2009;583(12):2121–5.CrossRefGoogle Scholar
  3. 3.
    Tsai TH, Chai HT, Sun CK, et al. Obesity suppresses circulating level and function of endothelial progenitor cells and heart function. J Transl Med. 2012;10:137.CrossRefGoogle Scholar
  4. 4.
    De Ciuceis C, Rossini C, Porteri E, et al. Circulating endothelial progenitor cells, microvascular density and fibrosis in obesity before and after bariatric surgery. Blood Press. 2013;22(3):165–72.CrossRefGoogle Scholar
  5. 5.
    Bellows CF, Zhang Y, Simmons PJ, et al. Influence of BMI on level of circulating progenitor cells. Obesity (Silver Spring). 2011;19(8):1722–6.CrossRefGoogle Scholar
  6. 6.
    Aldridge LM. Anaesthetic problems in myotonic dystrophy. A case report and review of the Aberdeen experience comprising 48 general anaesthetics in a further 16 patients. Br J Anaesth. 1985;57(11):1119–30.CrossRefGoogle Scholar
  7. 7.
    Mathieu J, Allard P, Gobeil G, et al. Anesthetic and surgical complications in 219 cases of myotonic dystrophy. Neurology. 1997;49(6):1646–50.CrossRefGoogle Scholar
  8. 8.
    LaDonna KA, Koopman WJ, Venance SL. Myotonic dystrophy (DM1) and dysphagia: the need for dysphagia management guidelines and an assessment tool. Can J Neurosci Nurs. 2011;33(1):42–6.Google Scholar
  9. 9.
    Steenackers N, Gesquiere I, Matthys C. The relevance of dietary protein after bariatric surgery: what do we know? Curr Opin Clin Nutr Metab Care. 2018;21(1):58–63.CrossRefGoogle Scholar
  10. 10.
    van den Broek M, de Heide LJ, Veeger NJ, et al. Influence of dietary protein and its amino acid composition on postoperative outcomes after gastric bypass surgery: a systematic review. Nutr Rev. 2016;74(12):749–73.CrossRefGoogle Scholar
  11. 11.
    Hakansson K, Kostic S, Lindberg C. Surgical treatment of obesity in DM1--a case report and a review of the literature. Neuromuscul Disord. 2015;25(5):414–7.CrossRefGoogle Scholar
  12. 12.
    Graziani F, Leone AM, Basile E, et al. Endothelial progenitor cells in morbid obesity. Circ J. 2014;78(4):977–85.CrossRefGoogle Scholar
  13. 13.
    Loro E, Rinaldi F, Malena A, et al. Normal myogenesis and increased apoptosis in myotonic dystrophy type-1 muscle cells. Cell Death Differ. 2010;17(8):1315–24.CrossRefGoogle Scholar
  14. 14.
    Fenech M. Micronucleus frequency in human lymphocytes is related to plasma vitamin B12 and homocysteine. Mutat Res. 1999;428(1–2):299–304.CrossRefGoogle Scholar
  15. 15.
    Koury MJ, Ponka P. New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Annu Rev Nutr. 2004;24:105–31.CrossRefGoogle Scholar
  16. 16.
    Richards WO, Prutzman KB, O'Hea MF, et al. Bariatric surgery improves the circulating numbers and biological activity of late outgrowth endothelial progenitor cells. Surg Obes Relat Dis. 2014;10(5):906–13.CrossRefGoogle Scholar
  17. 17.
    Sassoli C, Pini A, Chellini F, et al. Bone marrow mesenchymal stromal cells stimulate skeletal myoblast proliferation through the paracrine release of VEGF. PLoS One. 2012;7(7):e37512.CrossRefGoogle Scholar
  18. 18.
    Vassilev G, Hasenberg T, Krammer J, et al. The phase angle of the bioelectrical impedance analysis as predictor of post-bariatric weight loss outcome. Obes Surg. 2017;27(3):665–9.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Exercise Physiology Lab, ETH ZurichInstitute of Human Movement Sciences and SportZurichSwitzerland
  2. 2.Department of Internal Medicine IUniversity of LuebeckLuebeckGermany
  3. 3.eSwiss Medical and Surgical CenterSt. GallenSwitzerland

Personalised recommendations