Obesity Surgery

, Volume 29, Issue 2, pp 651–690 | Cite as

Evaluation of all Types of Metabolic Bariatric Surgery and its Consequences: a Systematic Review and Meta-Analysis

  • Matin Khosravi-Largani
  • Marzieh Nojomi
  • Rokhsareh Aghili
  • Hamidreza Alizadeh Otaghvar
  • Kiarash Tanha
  • Seyyed Hashem Sezavar Seyedi
  • Azadeh MottaghiEmail author
Review Article



Considering conflicting results on the consequences of all types of obesity surgery, we were to summarize them via a systematic review.


Electronic literature search was done via scientific search engines. After the removal of duplicates and selection of articles of interest, 771 studies were included.


Insulin resistance indicators were significantly improved after bariatric surgery. Leptin was also significantly decreased while adiponectin was significantly increased. Although the level of metabolic hormones changed after bariatric surgery, they were not statistically significant. Inflammation indicators were significantly decreased. Significant reduction was also detected in PAI-1 and sICAM-1.


Bariatric surgery is beneficial in morbidly obese patients. Although treating obesity in a surgical way may cause some complications, the weight loss is generally safe and effective.


Obesity Bariatric surgery Metabolic Weight Insulin resistance 



Research reported in this publication was supported by the Elite Researcher Grant Committee under award number 958714 from the National Institutes for Medical Research Development (NIMAD), Tehran, Iran.

Compliance with Ethical Standards

Conflict of Interest

Author 2 reports grants from National Institutes for Medical Research Development (NIMAD), during the conduct of the study. All of the other authors report no conflict of interest.

Informed Consent Statement

Informed consent does not apply.

Ethical Approval Statement

This article does not contain any studies with human participants or animals performed by any of the authors.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Medical Student, School of MedicineIran University of Medical SciencesTehranIran
  2. 2.Department of Community and Family Medicine, Preventive Medicine & Public Health Research Center, School of MedicineIran University of Medical SciencesTehranIran
  3. 3.Endocrine Research Center, Institute of Endocrinology and MetabolismIran University of Medical SciencesTehranIran
  4. 4.Trauma and Injury Research CenterIran University of Medical SciencesTehranIran
  5. 5.Department of Biostatistics, School of Public HealthIran University of Medical SciencesTehranIran
  6. 6.Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology & MetabolismIran University of Medical SciencesTehranIran

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