Bariatric Surgery and Hepatocellular Carcinoma: a Propensity Score-Matched Analysis
The association between obesity and rising incidence of hepatocellular carcinoma (HCC) in the USA has been documented; however, the role of bariatric surgery remains less clear.
To evaluate the cross-sectional association of prior-bariatric surgery and HCC.
The United States Nationwide Inpatient Sample (NIS) database was queried from 2004 to 2014 for discharges with a diagnosis of morbid obesity. Primary outcomes of interest were HCC and in-hospital mortality rate. Secondary outcomes were length of stay and cost. Baseline characteristics were balanced using propensity score matching (PSM). Using Poisson and logistic regressions, adjusted HCC prevalence ratio (PR) and mortality odds ratio (OR) were derived in patients with prior-bariatric surgery compared to those without bariatric surgery.
Of the 2,881,414 patients included in our study, 267,082 (9.3%) underwent bariatric surgery. From 2004 to 2014, there was a threefold increase in age-adjusted prevalence of HCC from 27 per 100,000 to 72 per 100,000 (PTrend < 0.001). After PSM, 230,956 patients with prior-bariatric surgery were matched with 230,956 patients without bariatric surgery. Prior-bariatric surgery was associated with lower prevalence of HCC (PR 0.11; 95% CI, 0.03–0.48; P < 0.001). In-hospital mortality was also lower for patients with surgery (OR 0.22; 95% CI, 0.20–0.26; P < 0.001). The occurrence of HCC added $18,840 extra cost, increased mean length of stay by 2 (95% CI; 1–3) days, and increased risk of death by 65% (aOR 1.65; 95% CI 1.18–2.29).
In this nationwide study of morbidly obese patients, prior-bariatric surgery was associated with a lower prevalence of HCC and lower in-patient mortality.
KeywordsObesity Bariatric surgery Weight loss Hepatocellular carcinoma (HCC)
This study is financially supported by NIH 5 T32 DK 7356-37 (BN).
Study concept and design—Njei B, McCarty TR, and Sharma P
Paper preparation—Njei B, McCarty TR, and Sharma P
Statistical analysis—Njei B
Critical revisions—McCarty TR, Sharma P, Lange A, Najafian N, Ngu JN, VE Ngomba, Echouffo-Tcheugui JB
Compliance with Ethical Standards
All authors approved of the final version of the manuscript.
This article has not been published and is not under consideration elsewhere.
Conflict of Interest
The authors declare that they have no conflicts of interest.
Ethical Approval Statement
For this type of study formal consent is not required.
Informed Consent Statement
Does not apply.
All checklist items for cross-sectional studies have been completed.
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