Magnesium Sulfate Reduced Opioid Consumption in Obese Patients Undergoing Sleeve Gastrectomy: a Prospective, Randomized Clinical Trial
The purpose of the study was to investigate the effect of magnesium sulfate on pain management for pain after sleeve gastrectomy operation.
A prospective, randomized, placebo-controlled clinical study.
Eighty patients undergoing sleeve gastrectomy.
Measurements and Main Results
Visual analog scale for the evaluation of pain, sedation score, mean arterial pressure, heart rate, and total analgesic consumption was recorded. Serum magnesium levels were determined before the operation, at the end of the operation, and at 24 h. There were no significant differences between the groups with respect to demographics, and sedation scores. Cumulative morphine consumption and pain scores were found to be higher in the control group than the magnesium group.
Perioperative use of magnesium sulfate reduced postoperative pain and opioid consumption in obese patients undergoing sleeve gastrectomy operations.
KeywordsPostoperative pain Magnesium sulfate Sleeve gastrectomy Bariatric surgery
Compliance with Ethical Standards
All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.
Conflict of Interest
The authors declare that they have no conflict of interest.
- 3.Christel AL, Raaff d, de Vries N, et al. Obstructive sleep apnea and bariatric surgical guidelines: summary and update. Curr Opin Anesthesiol. 2018;31:104–9.Google Scholar
- 6.Koinig H, Wallner T, Marhofer P, et al. Magnesium sulfate reduces intra- and postoperative analgesic requirements. Anesth Analg. 1998;87:206–10.Google Scholar
- 17.de Beer JDV, Winemaker MJ, Donnelly GAE, et al. Efficacy and safety of controlled-release oxycodone and standard therapies for postoperative pain after knee or hip replacement. Can J Surg. 2005;48:277–83.Google Scholar
- 22.Katherine KYL, Wilfred LMM. Multimodal analgesia model to achieve low postoperative opioid requirement following bariatric surgery. Hong Kong Med J. 2016;22(5):428–34.Google Scholar
- 31.Taheri A, Haryalchi K, Mansour Ghanaie M, et al. Effect of low-dose (single-dose) magnesium sulfate on postoperative analgesia in hysterectomy patients receiving balanced general anesthesia. Anesthesiol Res Pract. 2015;1:306145.Google Scholar