Obesity Surgery

, Volume 28, Issue 9, pp 2705–2711 | Cite as

FABP2, LEPR223, LEP656, and FTO Polymorphisms: Effect on Weight Loss 2 Years After Bariatric Surgery

  • Natália Luiza KopsEmail author
  • Manoela A. Vivan
  • Jaqueline D. C. Horvath
  • Mariana L. D. de Castro
  • Rogério Friedman
Original Contributions



Differences in weight loss outcomes after bariatric surgery may be related to individual preoperative characteristics. The aim of this study was to evaluate the potential effect of fatty acid binding protein-2 (rs1799883), leptin receptor (LEP223, rs1137101 and LEP656, rs1805094), and fat mass and obesity-related (rs9939609) genotypes on weight loss 2 years after bariatric surgery in Brazilian patients.

Materials and Methods

Prospective observational study involving 105 patients (lost to follow-up, 25.7%). In the preoperative period, patients were clinically evaluated and a fasting blood sample for genetic analysis (by real-time DNA amplification technique) was collected. From the patient’s medical records, follow-up weight loss (3, 6, 12, 24 months) was obtained. Percentage of excess weight loss (%EWL) was examined by pairwise comparison across the polymorphisms.


At baseline, the mean weight was 127.5 (23.3) kg and age 43.1 (10.9) years old. The %EWL was significant over time (p < 0.01). Only the LEP223 genotype showed association (p < 0.01). Up to 6 months after surgery, no differences were observed. At 12 months, a significant difference (p = 0.03) between AA (n = 19) and GG (n = 34) groups was observed, with 76.5% EWL versus 52.0%, respectively. This difference remained at 24 months. Other genotypes did not present any significant association.


There is a different evolution of weight loss in carriers of the LEP223 after bariatric surgery. The AA genotype seems to be associated with a higher weight loss. However, this pattern was evident only at 12 months after surgery.


Bariatric surgery Weight loss Polymorphism Genotype 


Author Contribution

The manuscript has been read and approved by all authors.

Funding Information

This work was supported by Fundo de Incentivo à Pesquisa e Eventos do Hospital de Clínicas de Porto Alegre (no. 12-0232), Conselho Nacional de Desenvolvimento Científico e Tecnológico (N. L. K., no. 119697, 2012), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (J. D. C. H., no. 118907, 2008).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Natália Luiza Kops
    • 1
    • 2
    Email author
  • Manoela A. Vivan
    • 3
  • Jaqueline D. C. Horvath
    • 1
    • 2
  • Mariana L. D. de Castro
    • 1
  • Rogério Friedman
    • 1
    • 4
  1. 1.Post-Graduate Program in EndocrinologyFederal University of Rio Grande do Sul (UFRGS)Porto AlegreBrazil
  2. 2.Hospital Moinhos de VentoPorto AlegreBrazil
  3. 3.Federal University of Rio Grande do Sul (UFRGS)Porto AlegreBrazil
  4. 4.Endocrinology DivisionHospital de Clínicas de Porto AlegrePorto AlegreBrazil

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