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Obesity Surgery

, Volume 28, Issue 8, pp 2421–2428 | Cite as

Sleeve Gastrectomy Recovering Disordered Brain Function in Subjects with Obesity: a Longitudinal fMRI Study

  • Panlong Li
  • Han Shan
  • Shengxiang Liang
  • Binbin Nie
  • Hua Liu
  • Shaofeng Duan
  • Qi Huang
  • Tianhao Zhang
  • Guanglong Dong
  • Yulin Guo
  • Jin Du
  • Hongkai Gao
  • Lin MaEmail author
  • Demin LiEmail author
  • Baoci ShanEmail author
Original Contributions

Abstract

Objective

Bariatric surgery could recover regional dysfunction of cerebral cortex. However, it is unknown whether bariatric surgery could recover the global-level dysfunction in subjects with obesity. The aim of this study was to investigate the effect of bariatric surgery on global-level dysfunction in subjects with obesity by resting-state functional magnetic resonance imaging (fMRI).

Methods

Resting-state fMRI was used to investigate dysfunction of whole-brain in 34 subjects with obesity and 34 age-and gender-matched normal-weight subjects, in which 17 subjects with obesity received sleeve gastrectomy. Fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC) among the whole brain were used to estimate the brain functional differences among the preoperative subjects, postoperative subjects, and the controls.

Results

The preoperative subjects compared to controls had decreased resting-state activities in reward processing and cognitive control regions such as orbitofrontal cortex, middle frontal gyrus, superior frontal gyrus, and gyrus rectus. It was important that increased FC was also found in these regions. Correlation analysis showed that body mass index (BMI) was associated with these decreased activity and increased FC. More importantly, the dysfunction in these regions was recovered by the bariatric surgery.

Conclusions

These results suggest that bariatric surgery-induced weight loss could reverse the global-level dysfunction in subjects with obesity. The dysfunction in these regions might play a key role in the development of obesity, which might serve as a biomarker in the treatment of obesity.

Keywords

Magnetic resonance imaging Obesity Bariatric surgery Functional connectivity Brain 

Notes

Acknowledgements

The authors thank the patients and healthy volunteers who took part in this study.

Funding

This work was supported by the National Natural Science Foundation of China [grant numbers 81471741, 81471728, and 81671770].

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Consent Statement

Informed consent was obtained from all individual participants included in the study.

Supplementary material

11695_2018_3178_MOESM1_ESM.docx (18 kb)
Supplementary Table 1 (DOCX 17 kb)
11695_2018_3178_MOESM2_ESM.docx (14 kb)
Supplementary Table 2 (DOCX 14 kb)
11695_2018_3178_MOESM3_ESM.docx (17 kb)
Supplementary Table 3 (DOCX 17 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PhysicsZhengzhou UniversityZhengzhouChina
  2. 2.Division of Nuclear Technology and Applications, Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina
  3. 3.Beijing Engineering Research Center of Radiographic Techniques and EquipmentBeijingChina
  4. 4.Department of RadiologyChinese People’s Liberation Army General HospitalBeijingChina
  5. 5.Department of General SurgeryChinese People’s Liberation Army General HospitalBeijingChina
  6. 6.Department of EndocrinologyChinese People’s Liberation Army General HospitalBeijingChina
  7. 7.Department of General Surgerythe General Hospital of Chinese People’s Armed Police ForcesBeijingChina
  8. 8.CAS Center for Excellence in Brain Science and Intelligence TechnologyShanghaiChina
  9. 9.Department of PhysicsUniversity of Chinese Academy of SciencesBeijingChina

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