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Obesity Surgery

, Volume 28, Issue 5, pp 1433–1440 | Cite as

Does Bariatric Surgery Affect the Incidence of Endometrial Cancer Development? A Systematic Review

  • Alec A Winder
  • Malsha Kularatna
  • Andrew D. MacCormick
Review Article

Abstract

Obesity has been linked to an increased prevalence in multiple cancers. Studies have suggested a reduction in the overall risk of cancer after bariatric surgery. We reviewed the evidence for bariatric surgery reducing the risk of endometrial cancer. Data was extracted from PubMed, EMBASE, and Medline to perform a systematic review. Thirty-one full text articles were identified from 265 abstracts. Nine observational studies were relevant to endometrial cancer. In the five controlled studies, 462 of 113,032 (0.4%) patients receiving bariatric surgery versus 11,997 of 848,864 (1.4%) controls developed endometrial cancer, odds ratio of 0.317 (95% CI 0.161 to 0.627) using random effects model (P < 0.001). Bariatric surgery seems to reduce the risk of endometrial cancer; however, more research is required.

Keywords

Obesity Bariatric surgery Weight loss Endometrial cancer Endometrial hyperplasia Risk reduction Systematic review 

Notes

Acknowledgements

The authors acknowledge Avinesh Pillai for his assistance with statistical analysis from the University of Auckland.

Compliance with Ethical Standards

For this type of study, formal consent was not required. This article does not contain any studies with human participants or animals performed by any of the authors.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Alec A Winder
    • 1
    • 2
  • Malsha Kularatna
    • 1
  • Andrew D. MacCormick
    • 1
    • 3
  1. 1.Department of General SurgeryMiddlemore Hospital, Counties Manukau HealthAucklandNew Zealand
  2. 2.LondonUK
  3. 3.Department of SurgeryUniversity of AucklandAucklandNew Zealand

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