Comparison of the Bile Reflux Frequency in One Anastomosis Gastric Bypass and Roux-en-Y Gastric Bypass: a Cohort Study

  • Behrouz Keleidari
  • Mohsen MahmoudiehEmail author
  • Amir Hosein Davarpanah Jazi
  • Hamid Melali
  • Farid Nasr Esfahani
  • Mohammad Minakari
  • Mojgan Mokhtari
Original Contributions



One of the most acceptable procedures in bariatric surgery is laparoscopic gastric bypass. Laparoscopic Roux-en-Y gastric bypass (RYGB) is a common technique used in bariatric surgery. Recently, one anastomosis gastric bypass (OAGB) has been suggested as a simple, fast, and effective technique for obesity treatment. This study aims to compare the frequency of histologically proven bile reflux in OAGB and RYGB among patients with morbid obesity.


This prospective cohort study was performed from 2015 to 2017 in the Department of Bariatric Surgery of Isfahan University of Medical Sciences, Isfahan, Iran. Patients who had undergone RYGB or OAGB surgery were enrolled. Patients who had undergone revisional surgery were excluded. Data on demographics, symptoms, fasting blood sugar, lipid profile, endoscopic, and histologic findings (based on the Sydney bile reflux index) of bile reflux and postoperative complications were collected and compared for the two techniques.


A total of 122 obese patients (22 males) who had undergone RYGB or OAGB surgery were included. The Sydney bile reflux index showed no statistically significant difference between RYGB and OAGB groups. Similarly, no statistically significant difference was found in the self-reported history of bile reflux–related symptoms, bile reflux markers in esophagogastroduodenoscopy, and postoperative complications between groups.


OAGB and RYGB appear to be equal with respect to postoperative complications, bile reflux frequency, bile reflux index, and the Sydney system score.


Roux-en-Y gastric bypass Omega gastric bypass One anastomosis gastric bypass Bile reflux Morbid obesity 



We would like to express our very great appreciation to Dr. Shervin Badihian for his valuable comments and suggestions during several stages of this research.

Compliance with Ethical Standards

This study was approved by the Ethical research committee of Isfahan University of Medical Sciences, and all participants provided written voluntary informed consent

Conflict of Interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Minimally Invasive Surgery Research CenterIsfahan University of Medical SciencesIsfahanIran
  2. 2.Department of Minimally Invasive SurgeryAl Zahra HospitalIsfahanIran
  3. 3.Student Research CommitteeSchool of Medicine, Isfahan University of Medical SciencesIsfahanIran
  4. 4.Department of GastroenterologyIsfahan University of Medical SciencesIsfahanIran
  5. 5.Department of PathologyIsfahan University of Medical SciencesIsfahanIran

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