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Comparison of Diabetes Remission and Micronutrient Deficiency in a Mildly Obese Diabetic Rat Model Undergoing SADI-S Versus RYGB

  • Tingfeng Wang
  • Yunlong Shen
  • Zhengdong Qiao
  • Yueqian Wang
  • Peng Zhang
  • Bo Yu
Original Contribution
  • 32 Downloads

Abstract

Background

Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) has launched a huge challenge to classic Roux-en-Y gastric bypass (RYGB). Our objective was to compare diabetes remission and micronutrient deficiency in a mildly obese diabetic rat model undergoing SADI-S versus RYGB.

Methods

Thirty adult male mildly obese diabetic rats were randomly assigned to sham (S), SADI-S, and RYGB groups. Body weight, food intake, fasting plasma glucose (FPG), oral glucose tolerance test (OGTT), plasma insulin, GLP-1, and ghrelin levels were measured at indicated time points. Meanwhile, insulin sensitivity and pancreatic β cell function were assessed during OGTT. Finally, plasma micronutrient evaluation and islet β cell mass analysis were performed after all animals were sacrificed.

Results

As compared to sham, the SADI-S and RYGB groups achieved almost equivalent efficacy in caloric restriction and FPG control without excessive weight loss. During OGTT, the SADI-S and RYGB groups also provided comparable effects on glycemic excursion, insulin sensitivity, and β cell function; however, only rats in the RYGB group showed significant changes in gut hormones, whereas the three groups were found to exhibit no significant difference in β cell mass. In addition, only vitamin E in the RYGB group was deficient as compared with the SADI-S and S groups.

Conclusion

In mildly obese diabetic rat, SADI-S and RYGB procedures have comparable efficacy in diabetes remission and risk of micronutrient deficiency. These data show that each of the surgery accomplishes diabetes improvements through both overlapping and distinct mechanisms requiring further investigation.

Keywords

Roux-en-Y gastric bypass Single-anastomosis duodeno-ileal bypass Diabetes remission Micronutrient 

Notes

Acknowledgments

The authors would like to thank Dr. Tao Yang for his excellent language editing support and valuable suggestions for manuscript revision. And thanks are also due to Ting Cao, Wen Wu, and Xiong Zhang for assistance with the experiments. This study was supported by the Science and Technology Development Fund of Shanghai Pudong New Area (Grant No. PKJ2015-Y35).

Compliance with Ethical Standards

The study protocol was reviewed and approved by the Institutional Animal Care and Utilization Committee (IACUC) of Fudan University Pudong Medical Center.

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

The research followed all applicable institutional and/or national guidelines for the care and use of animals, as well as was performed according to the recommendations of the Guide for the Care and Use of Laboratory Animals of the Ministry of Health, China.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Center for Metabolic and Bariatric SurgeryShanghai Pudong Hospital, Fudan University Pudong Medical CenterShanghaiChina
  2. 2.Center for Medical Research and InnovationShanghai Pudong Hospital, Fudan University Pudong Medical CenterShanghaiChina

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