Obesity Surgery

, Volume 27, Issue 9, pp 2471–2478 | Cite as

The Role of Endoscopic Intra-Gastric Botulinum Toxin-A for Obesity Treatment

  • Hadya Elshakh
  • Khalid El-Ejji
  • Shahrad TaheriEmail author
Review Article


Obesity prevalence has been increasing with devastating health and economic consequences. Botulinum toxin type A (BTX-A), a neurotoxin, is used clinically for conditions characterized by prolonged muscular contraction. Its inhibitory effects on gastric smooth muscles, in theory, make it a potential agent for obesity treatment through delayed gastric emptying and increased satiety. This review aims to examine the evidence for the use of endoscopic BTX-A injection for treating obesity. The literature search identified 60 articles with 11 primary studies as relevant for the scope of the review. Several studies have been conducted to examine the effect of BTX-A injections on obesity, including both animal and human studies. Current evidence from identified studies does not demonstrate sustained weight loss through the use of endoscopic BTX-A injection.


Botulinum toxin-A Endoscopy Obesity 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interested.

Statement of Informed Consent


Statement of Human/Animal Rights



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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Clinical Research CoreWeill Cornell Medicine-Qatar, Qatar Foundation—Education CityDohaQatar
  2. 2.Department of GastroenterologyHamad Medical CorporationDohaQatar
  3. 3.National Obesity Centre, Qatar Metabolic InstituteHamad Medical CorporationDohaQatar
  4. 4.Department of MedicineWeill Cornell MedicineNew YorkUSA
  5. 5.Department of MedicineWeill Cornell MedicineDohaQatar

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