Obesity Surgery

, Volume 27, Issue 2, pp 483–484 | Cite as

Letter to the Editor: Vagal Blocking (vBloc) Therapy: a New Era of Clinical Therapy for Extreme Obesity

Re: Apovian et al. Two-Year Outcomes of Vagal Nerve Blocking (vBloc) for the Treatment of Obesity in the ReCharge Trial. Obesity Surgery. 2016.
  • Shannon K. Boi
  • Justin X. Moore
  • Kendra J. Royston
  • Wendy Demark-Wahnefried
Letter to the Editor


  1. 1.
    Akinyemiju T, Meng Q, Vin-Raviv N. Association between body mass index and in-hospital outcomes: analysis of the nationwide inpatient database. Medicine (Baltimore). 2016;95(28):e4189. doi:10.1097/MD.0000000000004189.CrossRefPubMedCentralGoogle Scholar
  2. 2.
    Chan DS, Vieira AR, Aune D, et al. Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies. Ann Oncol. 2014;25(10):1901–14. doi:10.1093/annonc/mdu042.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Demark-Wahnefried W, Platz EA, Ligibel JA, et al. The role of obesity in cancer survival and recurrence. Cancer Epidemiol Biomark Prev. 2012;21(8):1244–59. doi:10.1158/1055-9965.EPI-12-0485.CrossRefGoogle Scholar
  4. 4.
    Doleman B, Mills KT, Lim S, et al. Body mass index and colorectal cancer prognosis: a systematic review and meta-analysis. Tech Coloproctol. 2016;20(8):517–35. doi:10.1007/s10151-016-1498-3.CrossRefPubMedGoogle Scholar
  5. 5.
    Nagle CM, Dixon SC, Jensen A, et al. Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium. Br J Cancer. 2015;113(5):817–26. doi:10.1038/bjc.2015.245.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Aguilar M, Bhuket T, Torres S, et al. Prevalence of the metabolic syndrome in the United States, 2003-2012. JAMA. 2015;313(19):1973–4. doi:10.1001/jama.2015.4260.CrossRefPubMedGoogle Scholar
  7. 7.
    Ogden CL, Carroll MD, Fryar CD, et al. Prevalence of obesity among adults and youth: United States, 2011-2014. NCHS Data Brief. 2015;219:1–8.Google Scholar
  8. 8.
    Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9945):766–81. doi:10.1016/S0140-6736(14)60460-8.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Apovian CM, Shah SN, Wolfe BM, et al. Two-year outcomes of vagal nerve blocking (vBloc) for the treatment of obesity in the ReCharge trial. Obes Surg. 2016; doi:10.1007/s11695-016-2325-7.Google Scholar
  10. 10.
    Pavlov VA, Tracey KJ. The vagus nerve and the inflammatory reflex—linking immunity and metabolism. Nat Rev Endocrinol. 2012;8(12):743–54. doi:10.1038/nrendo.2012.189.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004;4(8):579–91. doi:10.1038/nrc1408.CrossRefPubMedGoogle Scholar
  12. 12.
    Hale M, Itani F, Buchta CM, et al. Obesity triggers enhanced MDSC accumulation in murine renal tumors via elevated local production of CCL2. PLoS One. 2015;10(3):e0118784. doi:10.1371/journal.pone.0118784.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    James BR, Tomanek-Chalkley A, Askeland EJ, et al. Diet-induced obesity alters dendritic cell function in the presence and absence of tumor growth. J Immunol. n189(3):1311–21. doi:10.4049/jimmunol.1100587.

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Shannon K. Boi
    • 1
    • 2
  • Justin X. Moore
    • 1
    • 3
  • Kendra J. Royston
    • 1
    • 4
  • Wendy Demark-Wahnefried
    • 1
    • 5
  1. 1.University of Alabama at Birmingham (UAB) Comprehensive Cancer CenterUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Graduate Biomedical Sciences – Immunology ThemeUniversity of Alabama at BirminghamBirminghamUSA
  3. 3.Department of EpidemiologyUniversity of Alabama at BirminghamBirminghamUSA
  4. 4.Department of BiologyUniversity of Alabama at BirminghamBirminghamUSA
  5. 5.Department of Nutrition SciencesUniversity of Alabama at BirminghamBirminghamUSA

Personalised recommendations