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Obesity Surgery

, Volume 27, Issue 3, pp 703–708 | Cite as

GLP-1 and GLP-2 Levels are Correlated with Satiety Regulation After Roux-en-Y Gastric Bypass: Results of an Exploratory Prospective Study

  • Everton CazzoEmail author
  • José Carlos Pareja
  • Elinton Adami Chaim
  • Bruno Geloneze
  • Maria Rita Lazzarini Barreto
  • Daniéla Oliveira Magro
Original Contributions

Abstract

Background

Changes in satiety regulation are known to play a pivotal role in the weight loss effects of Roux-en-Y gastric bypass (RYGB) and the mechanisms by which these changes occur are not entirely known. There are previous reports of the influence of GLP-1 to cause enhancement of satiation, but in regard to GLP-2, it remains unclear. This study aimed to determine whether there is a correlation between the levels of GLP-1 and GLP-2 and satiety regulation following RYGB.

Materials and Methods

An exploratory prospective cohort study was made which enrolled 11 individuals who underwent RYGB and were followed-up for 12 months. GLP-1 and GLP-2 levels were determined before and after surgery and correlated with visual analogue scale scores for satiety.

Results

GLP-2 AUC after standard meal tolerance test (MTT) was significantly higher following surgery (945.3 ± 449.1 versus 1787.9 ± 602.7; p = 0.0037). Postoperatively, GLP-1 AUC presented a significant negative correlation with the mean score obtained in the first question of the visual analogue scale (“how hungry do you feel?”) (p = 0.008); GLP-2 AUC presented a significant positive correlation with the mean score of the third (“how full do you feel?”) question, and a significant positive correlation with the mean score achieved in the fourth question (“how much do you think you can eat?”), (p = 0.005 and p = 0.042, respectively).

Conclusion

GLP-1 and GLP-2 were significantly correlated with satiety assessment within this sample. Further research is necessary to confirm these findings.

Keywords

Bariatric surgery Obesity Gastric bypass Satiety response Glucagon-like peptides 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Statement of Informed Consent

Informed consent was obtained from all individual participants included in the study.

Statement of Human and Animal Rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.State University of Campinas (UNICAMP)CampinasBrazil

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