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Obesity Surgery

, Volume 26, Issue 2, pp 459–463 | Cite as

Energy Adaptations Persist 2 Years After Sleeve Gastrectomy and Gastric Bypass

  • Charmaine S. Tam
  • Georgia Rigas
  • Leonie K. Heilbronn
  • Tania Matisan
  • Yasmine Probst
  • Michael Talbot
Brief Communication

Abstract

Non-surgical weight loss induces a greater than expected decrease in energy expenditure, a phenomenon known as ‘metabolic adaptation’. The effects of different bariatric surgery procedures on metabolic adaptation are not yet known and may partially contribute to weight loss success. We compared resting energy expenditure (REE) in 35 subjects (nine males; age = 46 ± 11 years; BMI = 42.1 ± 6.5 kg/m2) undergoing gastric band, sleeve gastrectomy or Roux-en-Y gastric bypass (RYGB) up to 2 years after surgery. We found a greater than expected reduction of 130–300 kcal/day at 6 weeks after sleeve and bypass surgery which was not explained by changes in body composition; this change was not seen in the band group. The suppression in REE after sleeve and RYGB remained up to 2 years, even after weight loss had plateaued. Our findings suggest that energy adaptation is not a contributing mechanism to medium-term weight maintenance after sleeve and RYGB bariatric surgeries.

Keywords

Energy expenditure Resting metabolic rate Metabolic adaptation 

Notes

Compliance with Ethical Standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflict of Interest

All authors declare no conflict of interest.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Muller MJ, Bosy-Westphal A, Kutzner D, et al. Metabolically active components of fat-free mass and resting energy expenditure in humans: recent lessons from imaging technologies. Obes Rev. 2002;3(2):113–22.PubMedCrossRefGoogle Scholar
  2. 2.
    Rosenbaum M, Hirsch J, Gallagher DA, et al. Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr. 2008;88(4):906–12.PubMedGoogle Scholar
  3. 3.
    Knuth ND, Johannsen DL, Tamboli RA, et al. Metabolic adaptation following massive weight loss is related to the degree of energy imbalance and changes in circulating leptin. Obesity (Silver Spring). 2014;22(12):2563–9.Google Scholar
  4. 4.
    Heilbronn LK, de Jonge L, Frisard MI, et al. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA. 2006;295(13):1539–48.PubMedPubMedCentralCrossRefGoogle Scholar
  5. 5.
    Carrasco F, Papapietro K, Csendes A, et al. Changes in resting energy expenditure and body composition after weight loss following Roux-en-Y gastric bypass. Obes Surg. 2007;17(5):608–16.PubMedCrossRefGoogle Scholar
  6. 6.
    Butte NF, Brandt ML, Wong WW, et al. Energetic adaptations persist after bariatric surgery in severely obese adolescents. Obesity (Silver Spring). 2015;23(3):591–601.CrossRefGoogle Scholar
  7. 7.
    Faria SL, Faria OP, Cardeal MA, et al. Diet-induced thermogenesis and respiratory quotient after Roux-en-Y gastric bypass surgery: a prospective study. Surg Obes Relat Dis. 2014;10(1):138–43.PubMedCrossRefGoogle Scholar
  8. 8.
    Das SK, Roberts SB, McCrory MA, et al. Long-term changes in energy expenditure and body composition after massive weight loss induced by gastric bypass surgery. Am J Clin Nutr. 2003;78(1):22–30.PubMedGoogle Scholar
  9. 9.
    Dirksen C, Jorgensen NB, Bojsen-Moller KN, et al. Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass. Int J Obes (Lond). 2013;37(11):1452–9.CrossRefGoogle Scholar
  10. 10.
    de Castro CM, de Lima Montebelo MI, Rasera Jr I, et al. Effects of Roux-en-Y gastric bypass on resting energy expenditure in women. Obes Surg. 2008;18(11):1376–80.CrossRefGoogle Scholar
  11. 11.
    Fruhbeck G. Bariatric and metabolic surgery: a shift in eligibility and success criteria. Nat Rev Endocrinol. 2015;11(8):465–77.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Charmaine S. Tam
    • 1
  • Georgia Rigas
    • 2
  • Leonie K. Heilbronn
    • 3
  • Tania Matisan
    • 2
  • Yasmine Probst
    • 4
  • Michael Talbot
    • 2
  1. 1.The Charles Perkins Centre and School of Biological SciencesUniversity of SydneySydneyAustralia
  2. 2.Upper Gastrointestinal Unit, Department of SurgerySt George Private HospitalKogarahAustralia
  3. 3.Discipline of MedicineUniversity of AdelaideAdelaideAustralia
  4. 4.Smart Foods Centre, School of MedicineUniversity of WollongongWollongongAustralia

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