rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery
- 194 Downloads
We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p = .004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p < .05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.
KeywordsBariatric surgery Repeated measures Predictors Long-term weight loss Roux-en-Y gastric bypass SNP Obesity GWAS
- 1.Still CD, Wood GC, Chu X, et al. High allelic burden of four obesity SNPs is associated with poorer weight loss outcomes following gastric bypass surgery. Obesity (Silver Spring). 2011. doi:10.1038/oby.2011.3. Epub 2011/02/12. doi: oby20113 [pii]. PubMed PMID: 21311511.
- 2.Kakela P, Jaaskelainen T, Torpstrom J, et al. Genetic risk score does not predict the outcome of obesity surgery. Obes Surg. 2014;24(1):128–33. doi:10.1007/s11695-013-1080-2. PubMed PMID: 24065439.
- 3.Sarzynski MA, Jacobson P, Rankinen T, et al. Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. Int J Obes (Lond). 2010. doi:10.1038/ijo.2010.166. Epub 2010/08/25.
- 4.Baldridge AS, Pacheco JA, Aufox SA, et al. Factors associated with long-term weight loss following bariatric surgery using 2 methods for repeated measures analysis. Am J Epidemiol. 2015. doi:10.1093/aje/kwv039. PubMed PMID: 26093003.
- 5.Speliotes EK, Willer CJ, Berndt SI, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42(11):937–48. doi:10.1038/ng.686. Epub 2010/10/12. doi: ng.686 [pii] PubMed PMID: 20935630; PMCID: 3014648.PubMedCentralCrossRefPubMedGoogle Scholar
- 6.Heid IM, Jackson AU, Randall JC, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010;42(11):949–60. doi:10.1038/ng.685. Epub 2010/10/12. doi: ng.685 [pii].PubMed PMID: 20935629; PMCID: 3000924.PubMedCentralCrossRefPubMedGoogle Scholar
- 8.Mirshahi UL, Still CD, Masker KK, et al. The MC4R(I251L) allele is associated with better metabolic status and more weight loss after gastric bypass surgery. J Clin Endocrinol Metab. 2011;96(12):E2088–96. doi:10.1210/jc.2011-1549. PubMed PMID: 21976721; PMCID: 3232628.PubMedCentralCrossRefPubMedGoogle Scholar
- 10.Rinella ES, Still C, Shao Y, et al. Genome-wide association of single-nucleotide polymorphisms with weight loss outcomes after roux-en-Y gastric bypass surgery. J Clin Endocrinol Metab. 2013;98(6):E1131–6. doi:10.1210/jc.2012-3421. PubMed PMID: 23633212; PMCID: 3667258.PubMedCentralCrossRefPubMedGoogle Scholar