Obesity Surgery

, Volume 25, Issue 11, pp 2225–2229 | Cite as

rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

  • Laura J. Rasmussen-Torvik
  • Abigail S. Baldridge
  • Jennifer A. Pacheco
  • Sharon A. Aufox
  • Kwang-Youn A. Kim
  • Jonathan C. Silverstein
  • Erwin W. Denham
  • Eric Hungness
  • Maureen E. Smith
  • Philip Greenland
Brief Communication

Abstract

We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p = .004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p < .05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.

Keywords

Bariatric surgery Repeated measures Predictors Long-term weight loss Roux-en-Y gastric bypass SNP Obesity GWAS 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Laura J. Rasmussen-Torvik
    • 1
  • Abigail S. Baldridge
    • 1
  • Jennifer A. Pacheco
    • 2
  • Sharon A. Aufox
    • 2
  • Kwang-Youn A. Kim
    • 1
  • Jonathan C. Silverstein
    • 3
  • Erwin W. Denham
    • 3
  • Eric Hungness
    • 4
  • Maureen E. Smith
    • 2
  • Philip Greenland
    • 1
  1. 1.Department of Preventive MedicineNorthwestern University Feinberg School of MedicineChicagoUSA
  2. 2.Center for Genetic MedicineNorthwestern University Feinberg School of MedicineChicagoUSA
  3. 3.NorthShore Research InstituteNorthShore University Health SystemEvanstonUSA
  4. 4.Department of SurgeryNorthwestern University Feinberg School of MedicineChicagoUSA

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