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Obesity Surgery

, Volume 26, Issue 2, pp 276–281 | Cite as

Gender Influence on Long-Term Weight Loss and Comorbidities After Laparoscopic Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: a Prospective Study With a 5-Year Follow-up

  • Federico Perrone
  • Emanuela Bianciardi
  • Domenico Benavoli
  • Valeria Tognoni
  • Cinzia Niolu
  • Alberto Siracusano
  • Achille L. Gaspari
  • Paolo Gentileschi
Original Contributions

Abstract

Background

Gender might be important in predicting outcomes after bariatric surgery. The aim of the study was to investigate the influence of gender on long-term weight loss and comorbidity improvement after laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB).

Methods

A cohort of 304 consecutive patients underwent surgery in 2006–2009: 162 (98 women, 64 men) underwent LSG and 142 (112 women, 30 men) underwent LRYGB. The mean follow-up time was 75.8 ± 8.4 months (range, 60–96 months).

Results

Overall mean (95 % CI) reduction in BMI was 23.5 (24.3–22.7) kg/m2 after 5 years, with no statistical difference between LSG and LRYGB groups (P = 0.94). The overall means ± standard deviations of %EBMIL after 5 years were 78.8 ± 23.5 and 81.6 ± 21.4 in the LSG and LRYGB groups, respectively. Only for LSG group %EBMIL after 24–36 and 60 months differed significantly between male and female patients (P = 0.003 versus P = 0.06 in LRYGB), and 89 versus 90 % of patients showed improvements in comorbidities in the LSG and LRYGB groups, respectively. Only two patients (women) were lost to follow-up: 1/162 (0.6 %) for LSG at the 4th year and 1/142 (0.7 %) for LRYGB to the 5th year.

Conclusions

LSG was more effective in obese male than in female patients in terms of %EBMIL, with no difference in comorbidities. LRYGB elicited similar results in both genders in terms of %EBMIL and comorbidities.

Keywords

Obesity Predictors Gender Weight loss Bariatric surgery Sleeve gastrectomy Gastric Bypass 

Notes

Conflict of Interest

The authors declare that they have no competing interests.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Livhits M, Mercado C, Yennilov I, et al. Preoperative predictors of weight loss following bariatric surgery: systematic review. Obes Surg. 2011;22(l):70–89.Google Scholar
  2. 2.
    Biron S, Hould FS, Lebel S, et al. Twenty years of biliopancreatic diversion: what is the goal of the surgery? Obes Surg. 2004;14(2):160–4.PubMedCrossRefGoogle Scholar
  3. 3.
    Löfgren P, Hoffstedt J, Rydén M, et al. Major gender differences in the lipolytic capacity of abdominal subcutaneous fat cells in obesity observed before and after long-term weight reduction. J Clin Endocrinol Metab. 2002;87(2):764–71.PubMedCrossRefGoogle Scholar
  4. 4.
    Rutledge T, Adler S, Friedman R. A prospective assessment of psychosocial factors among bariatric versus non-bariatric surgery candidates. Obes Surg. 2011;21(10):1570–9.PubMedPubMedCentralCrossRefGoogle Scholar
  5. 5.
    Baltasar A, Deitcl M, Grecnstcin RJ. Weight loss reporting. Obes Surg. 2008;18(6):761–2.PubMedCrossRefGoogle Scholar
  6. 6.
    van de Laar AW. Algorithm for weight loss after gastric bypass surgery considering body mass index, gender, and age from the Bariatric Outcome Longitudinal Database (BOLD). Surg Obes Relat Dis. 2014;10(1):55–61. doi: 10.1016/j.soard.2013.05.008.PubMedCrossRefGoogle Scholar
  7. 7.
    Andersen JR, Aadland E, Nilsen RM, et al. Predictors of weight loss are different in men and women after sleeve gastrectomy. Obes Surg. 2014;24(4):594–8. doi: 10.1007/s11695-013-1124-7.PubMedCrossRefGoogle Scholar
  8. 8.
    Adams ST, Salhab M, Hussain ZI, et al. Roux-en-Y gastric bypass for morbid obesity: what are the preoperative predictors of weight loss? Postgrad Med J. 2013;89(1053):411–6. doi: 10.1136/postgradmedj-2012-131310.PubMedCrossRefGoogle Scholar
  9. 9.
    Morita N, Okita K. Is gender a factor in the reduction of cardiovascular risks with exercise training? Circ J. 2013;77(3):646–51.PubMedCrossRefGoogle Scholar
  10. 10.
    Ketterer C, Heni M, Stingl K et al. Polymorphism rs3123554 in CNR2 reveals genderspecific effects on body weight and affects loss of body weight and cerebral insulin action. Obesity (Silver Spring). 2014;22(3):925–31. doi: 10.1002/oby.20573.
  11. 11.
    Tiwari MM, Goede MR, Reynoso JF, et al. Differences in outcomes of laparoscopic gastric bypass. Surg Obes Relat Dis. 2011;7(3):277–82.PubMedCrossRefGoogle Scholar
  12. 12.
    Sucandy I, Antanavicius G. Comparative analysis of gender differences in outcomes after biliopancreatic diversion with duodenal switch: revisiting male gender as a predictor for adverse outcomes in bariatric surgery. Am Surg. 2013;79(5):543–4.PubMedGoogle Scholar
  13. 13.
    Stroh C, Groh C, Weiner R, et al. Are there gender-specific aspects of gastric banding? Data analysis from the quality assurance study of the surgical treatment of obesity in Germany. Obes Surg. 2013;23(11):1783–9.PubMedCrossRefGoogle Scholar
  14. 14.
    Scozzari G, Passera R, Benvenga R, et al. Age as a long-term prognostic factor in bariatric surgery. Ann Surg. 2012;256(5):724–8.PubMedCrossRefGoogle Scholar
  15. 15.
    Contreras JE, Santander C, Court I, et al. Correlation between age and weight loss after bariatric surgery. Obes Surg. 2013;23(8):1286–9.PubMedCrossRefGoogle Scholar
  16. 16.
    Kolotkin RL, Crosby RD, Williams GR. Health-related quality of life varies among obese subgroups. Obes Res. 2002;10(8):748–56.PubMedCrossRefGoogle Scholar
  17. 17.
    Ramanathan L, Siegel JM. Gender differences between hypocretin/orexin knockout and wild type mice: age, body weight, body composition, metabolic markers, leptin and insulin resistance. J Neurochem. 2014;131(5):615–24.PubMedCrossRefGoogle Scholar
  18. 18.
    Yen YC, Huang CK, Tai CM. Psychiatric aspects of bariatric surgery. Curr Opin Psychiatry. 2014;27(5):374–9.PubMedPubMedCentralCrossRefGoogle Scholar
  19. 19.
    Yousseif A, Emmanuel J, Karra E, et al. Differential effects of laparoscopic sleeve gastrectomy and laparoscopic gastric bypass on appetite, circulating acyl-ghrelin, peptide YY3-36 and active GLP-1 levels in non-diabetic humans. Obes Surg. 2014;24(2):241–52. doi: 10.1007/s11695-013-1066-0.PubMedPubMedCentralCrossRefGoogle Scholar
  20. 20.
    Bekheit M, Katri K, Ashour MH, et al. Gender influence on long-term weight loss after three bariatric procedures: gastric banding is less effective in males in a retrospective analysis. Surg Endosc. 2014;28(8):2406–11. doi: 10.1007/s00464-014-3489-7.PubMedCrossRefGoogle Scholar
  21. 21.
    Kennedy-Dalby A, Adam S, Ammori BJ, et al. Weight loss and metabolic outcomes of bariatric surgery in men versus women—a matched comparative observational cohort study. Eur J Intern Med. 2014;25(10):922–5. doi: 10.1016/j.ejim.2014.10.020.PubMedCrossRefGoogle Scholar
  22. 22.
    Murphy CM, Stojek MK, MacKillop J. Interrelationships among impulsive personality traits, food addiction, and body mass index. Appetite. 2014;73:45–50.PubMedCrossRefGoogle Scholar
  23. 23.
    Wandel M, Roos G. Work, food and physical activity. A qualitative study of coping strategies among men in three occupations. Appetite. 2005;44(1):93–102.PubMedCrossRefGoogle Scholar
  24. 24.
    Heitzmann CA, Kaplan RM, Wilson DK, et al. Sex differences in weight loss among adults with type II diabetes mellitus. J Behav Med. 1987;10(2):197–211.PubMedCrossRefGoogle Scholar
  25. 25.
    Wadden TA, Ncibcrg RH, Wing RR, et al. Four-year weight losses in the Look AHEAD study: factors associated with long-term success. Obesity (Silver Spring). 2011;19(10):1987–98.PubMedCentralCrossRefGoogle Scholar
  26. 26.
    Chiolero A, Faeh D, Paccaud F, et al. Consequences of smoking for body weight, body fat distribution, and insulin resistance. Am J Clin Nutr. 2008;87(4):801–9.PubMedGoogle Scholar
  27. 27.
    van Hout GC, Verschurc SK, van Heck GL. Psychosocial predictors of success following bariatric surgery. Obes Surg. 2005;15(4):552–60.PubMedCrossRefGoogle Scholar
  28. 28.
    Levine JA. Non exercise activity thermogenesis (NEAT): environment and biology. Am J Physiol Endocrinol Metab. 2004;286(5):E675–85.PubMedCrossRefGoogle Scholar
  29. 29.
    Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292:1724–37.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Federico Perrone
    • 1
  • Emanuela Bianciardi
    • 3
  • Domenico Benavoli
    • 1
  • Valeria Tognoni
    • 1
  • Cinzia Niolu
    • 3
  • Alberto Siracusano
    • 3
  • Achille L. Gaspari
    • 1
  • Paolo Gentileschi
    • 1
    • 2
  1. 1.General Surgery Unit, Department of Experimental Medicine and SurgeryUniversity of RomeTor VergataItaly
  2. 2.Bariatric Surgery Unit, Department of Experimental Medicine and SurgeryUniversity of RomeTor VergataItaly
  3. 3.Psychiatric Unit, Department of System MedicineUniversity of RomeTor VergataItaly

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