Obesity Surgery

, Volume 26, Issue 2, pp 276–281 | Cite as

Gender Influence on Long-Term Weight Loss and Comorbidities After Laparoscopic Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: a Prospective Study With a 5-Year Follow-up

  • Federico Perrone
  • Emanuela Bianciardi
  • Domenico Benavoli
  • Valeria Tognoni
  • Cinzia Niolu
  • Alberto Siracusano
  • Achille L. Gaspari
  • Paolo Gentileschi
Original Contributions



Gender might be important in predicting outcomes after bariatric surgery. The aim of the study was to investigate the influence of gender on long-term weight loss and comorbidity improvement after laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB).


A cohort of 304 consecutive patients underwent surgery in 2006–2009: 162 (98 women, 64 men) underwent LSG and 142 (112 women, 30 men) underwent LRYGB. The mean follow-up time was 75.8 ± 8.4 months (range, 60–96 months).


Overall mean (95 % CI) reduction in BMI was 23.5 (24.3–22.7) kg/m2 after 5 years, with no statistical difference between LSG and LRYGB groups (P = 0.94). The overall means ± standard deviations of %EBMIL after 5 years were 78.8 ± 23.5 and 81.6 ± 21.4 in the LSG and LRYGB groups, respectively. Only for LSG group %EBMIL after 24–36 and 60 months differed significantly between male and female patients (P = 0.003 versus P = 0.06 in LRYGB), and 89 versus 90 % of patients showed improvements in comorbidities in the LSG and LRYGB groups, respectively. Only two patients (women) were lost to follow-up: 1/162 (0.6 %) for LSG at the 4th year and 1/142 (0.7 %) for LRYGB to the 5th year.


LSG was more effective in obese male than in female patients in terms of %EBMIL, with no difference in comorbidities. LRYGB elicited similar results in both genders in terms of %EBMIL and comorbidities.


Obesity Predictors Gender Weight loss Bariatric surgery Sleeve gastrectomy Gastric Bypass 


Conflict of Interest

The authors declare that they have no competing interests.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Federico Perrone
    • 1
  • Emanuela Bianciardi
    • 3
  • Domenico Benavoli
    • 1
  • Valeria Tognoni
    • 1
  • Cinzia Niolu
    • 3
  • Alberto Siracusano
    • 3
  • Achille L. Gaspari
    • 1
  • Paolo Gentileschi
    • 1
    • 2
  1. 1.General Surgery Unit, Department of Experimental Medicine and SurgeryUniversity of RomeTor VergataItaly
  2. 2.Bariatric Surgery Unit, Department of Experimental Medicine and SurgeryUniversity of RomeTor VergataItaly
  3. 3.Psychiatric Unit, Department of System MedicineUniversity of RomeTor VergataItaly

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