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Obesity Surgery

, Volume 25, Issue 6, pp 1071–1072 | Cite as

Do Proton Pump Inhibitors Contribute to Weight Gain?

  • Yu-Fong Syu
  • Hsien-Hao Huang
  • Chih-Yen Chen
Letter to the Editor

Keywords

Gastric Bypass Omeprazole Proton Pump Inhibitor Excess Weight Loss Gastroesophageal Reflux Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This paper was sponsored by grants from the Taipei Veterans General Hospital, Taipei, Taiwan (V95C1-096 and V96C1-112) and in part from Taiwan Ministry of Science and Technology (MOST 103-2314-B-010-011-).

Conflict of interest

Dr. Yu-Fong Syu, Dr. Hsien-Hao Huang, and Dr. Chih-Yen Chen disclose no conflict of interest.

References

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    Ward EK, Schuster DP, Stowers KH, et al. The effect of PPI use on human gut microbiota and weight loss in patients undergoing laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2014;24(9):1567–71.CrossRefPubMedGoogle Scholar
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    Yoshikawa I, Nagato M, Yamasaki M, et al. Long-term treatment with proton pump inhibitor is associated with undesired weight gain. World J Gastroenterol. 2009;15(38):4794–8.CrossRefPubMedCentralPubMedGoogle Scholar
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    Cui GL, Syversen U, Zhao CM, et al. Long-term omeprazole treatment suppresses body weight gain and bone mineralization in young male rats. Scand J Gastroenterol. 2001;36(10):1011–5.CrossRefPubMedGoogle Scholar
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    Egan LJ, Myhre GM, Mays DC, et al. CYP2C19 pharmacogenetics in the clinical use of proton pump inhibitors for gastro-oesophageal reflux disease: variant alleles predict gastric acid suppression, but not oesophageal acid exposure or reflux symptoms. Aliment Pharmacol Ther. 2003;17(12):1521–8.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Family MedicineTaipei Veterans General HospitalTaipeiTaiwan
  2. 2.Department of Emergency MedicineTaipei Veterans General HospitalTaipeiTaiwan
  3. 3.Division of Gastroenterology, Department of MedicineTaipei Veterans General HospitalTaipeiRepublic of China
  4. 4.Faculty of MedicineNational Yang-Ming University School of MedicineTaipeiTaiwan

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