Obesity Surgery

, Volume 25, Issue 10, pp 1842–1847 | Cite as

Multicenter Randomized Study of Obesity Treatment with Minimally Invasive Injection of Hyaluronic Acid Versus and Combined with Intragastric Balloon

  • Jerome Dargent
  • François Mion
  • Vianna Costil
  • René Ecochard
  • Frédéric Pontette
  • Valentin Mion
  • Stéphane Angella
Original Contributions

Abstract

Background

Research into minimally invasive techniques is worthwhile for greater acceptance in bariatric surgery, a useful first step being to evaluate the combination of these with current procedures. We suggest that intragastric balloon (IGB) can be performed with hyaluronic acid (HA) injections at the level of the gastroesophageal junction.

Methods

A submucosal restriction is created by circular injection of an absorbable material within a defined area based on endoscopic anatomy. We included 101 patients in a prospective multicenter randomized trial, with average body mass index (BMI) 33.4 (range 27–44), treated from April 2010 to April 2012 by IGB and/or HA injection, sequentially, and followed for two more years. Patients were divided into group 1 (IGB alone), group 2 (IGB followed by HA at IGB removal, at 6 months), and group 3 (HA and IGB at 6 months).

Results

BMI loss at 6 months was inferior in the HA group (32 patients) compared with the IGB groups (68 patients) (2.1 ± 0.4 versus 3.4 ± 0.3, p < 0.05). The efficacy of IGB alone compared with combined treatments (groups 2 and 3) was significantly inferior at 18 months only, but the impact of the treatment sequence (HA before or after IGB) on BMI loss was not statistically significant, although in favor of HA first.

Conclusions

This study did not demonstrate the efficacy of HA injections as an obesity treatment.

Keywords

Obesity classes I–III Minimally invasive Endoscopy Intragastric balloon Hyaluronic acid injection 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Jerome Dargent
    • 1
  • François Mion
    • 2
  • Vianna Costil
    • 3
  • René Ecochard
    • 2
  • Frédéric Pontette
    • 1
  • Valentin Mion
    • 2
  • Stéphane Angella
    • 1
  1. 1.Polyclinique Lyon-NordRillieux-la-PapeFrance
  2. 2.Hôpital E. HerriotLyonFrance
  3. 3.Clinique du TrocadéroParisFrance

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