Laparoscopic Sleeve Gastrectomy Compared to a Multidisciplinary Weight Loss Program for Obesity—Effects on Body Composition and Protein Status
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Optimal obesity therapy is a matter of debate. Besides weight reduction, other criteria such as safety and nutritional status are of relevance. Therefore, we compared a favored surgical intervention with the most effective conservative treatment regarding anthropometry and nutritional status.
Fifty-four obese patients were included who underwent laparoscopic sleeve gastrectomy (LSG, n = 27) or a 52-week multidisciplinary intervention program (MIP, n = 27) for weight loss. Body weight, body composition assessed by bioelectrical impedance analysis, and serum protein levels were measured before and within 12 months after intervention.
After 1 year of observation, excess weight loss was more pronounced following LSG (65 %) compared to MIP (38 %, p < 0.001). In both groups, body fat was clearly reduced, but a higher reduction occurred in the LSG group. However, protein status deteriorated particularly in the LSG group. Within 1 year, body cell mass declined from 37.1 to 26.9 kg in the LSG group, but only from 35.7 to 32.2 kg in the MIP group. This resulted in an increased mean extracellular mass/body cell mass ratio (1.42 versus 1.00, p < 0.001), in a decreased mean phase angle (4.4° versus 6.6°, p < 0.001), and in a lower prealbumin level in serum (p < 0.02) in the LSG group compared to the MIP group.
LSG, compared to MIP, was more effective regarding excess weight loss and body fat loss within 1 year, however, induced more pronounced muscle mass and protein loss, possibly requiring particular interventions such as exercise or protein supplements.
KeywordsLaparoscopic sleeve gastrectomy Formula diet Body composition Protein–energy malnutrition Body cell mass Phase angle
This work was supported by the “Competence Network of Obesity,” research group “Obesity and the gastrointestinal tract,” coordinated by SCB and funded by the Federal Ministry of Education and Research, Germany (No. FKZ 01GI0843).
Conflict of interest
All authors declare no conflict of interest; they are all independent from the funding institutions. The authors are part of the Competence network of obesity, which is primarily funded by a research grant of the Federal Ministry of Education and Research, Germany. Within this network, the authors are funded in part by Covidien Germany GmbH, by Johnson & Johnson, Ethicon Endo-Surgery GmbH, Germany, and by Nestlé Inc., Germany. The sponsors had no influence in study design, analysis, and interpretation of data, as well as in the writing of the manuscript. No other relationships or activities exist that could appear to have influenced the submitted work.
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