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Obesity Surgery

, Volume 23, Issue 12, pp 2086–2091 | Cite as

Effect of Bariatric Surgery on Bone Mineral Density: Comparison of Gastric Bypass and Sleeve Gastrectomy

  • Nuria Vilarrasa
  • Amador G. Ruiz de Gordejuela
  • Carmen Gómez-Vaquero
  • Jordi Pujol
  • Iñaki Elio
  • Patricia San José
  • Silvia Toro
  • Anna Casajoana
  • José Manuel Gómez
Original Contributions

Abstract

The aim of our study was to compare bone mineral density (BMD) a year after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in age- and body mass index-matched women. In 33 morbidly obese women undergoing RYGB and 33 undergoing SG, plasma determinations of calcium, parathyroid hormone (PTH), 25-hydroxyvitamin D (25(OH) D3), and insulin-like growth factor-I (IGF-I) were made prior to and at 12 months after surgery. Dual-energy X-ray absorptiometry was performed in all patients 1 year after surgery. BMD at the femoral neck and the lumbar spine 1 year after surgery was similar in women undergoing RYGB and SG (1.01 ± 0.116 vs. 1.01 ± 0.122 g/cm2, p = 0.993; 1.05 ± 0.116 vs. 1.08 ± 0.123 g/cm2, p = 0.384). The percentage of patients with osteopenia and osteoporosis was not different between groups. In the linear regression analysis, age (β = −0.628, p = 0.034) and lean mass 12 months after surgery (β = 0.424, p = 0.021) were found to be the main determinants of femoral neck BMD. Age (β = −0.765, p = 0.025), menopause (β = −0.898, p = 0.033), and lean mass (β = 0.615, p = 0.023) were determinants of BMD at the lumbar spine. No influence was found between low bone mass and type of surgery, plasma PTH, 25(OH) D3, or IGF-I. The effect of RYGB and SG on BMD was comparable a year after surgery. Menopausal women were at a higher risk of having low bone mass, but the presence of osteoporosis was uncommon.

Keywords

Bone mineral density Gastric bypass Sleeve gastrectomy Lean mass PTH 25-Hydroxyvitamin D 

Notes

Acknowledgments

This work was supported by Fondo de Investigación Sanitaria (Grant FIS PI/11/01960) and Ajuts per a projectes de recerca clínica de l’Hospital Universitari de Bellvitge (2011-PR143/11).

Conflict of Interest

The authors have no conflicts of interest to disclose.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Nuria Vilarrasa
    • 1
  • Amador G. Ruiz de Gordejuela
    • 2
  • Carmen Gómez-Vaquero
    • 3
  • Jordi Pujol
    • 2
  • Iñaki Elio
    • 1
  • Patricia San José
    • 1
  • Silvia Toro
    • 1
  • Anna Casajoana
    • 2
  • José Manuel Gómez
    • 1
  1. 1.Endocrinology Service, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)Bellvitge University Hospital-IDIBELLBarcelonaSpain
  2. 2.Department of Bariatric SurgeryBellvitge University Hospital-IDIBELLBarcelonaSpain
  3. 3.Rheumatology ServiceBellvitge University Hospital-IDIBELLBarcelonaSpain

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