Obesity Surgery

, Volume 23, Issue 10, pp 1650–1654 | Cite as

Greater Short-Term Weight Loss in Women 20–45 versus 55–65 Years of Age Following Bariatric Surgery

  • Christopher N. Ochner
  • Julio Teixeira
  • Nori Geary
  • Lori Asarian
Clinical Research

Abstract

Background

Whether and how sex and age affect bariatric-surgery outcome is poorly understood. Estrogens regulate body composition in women and animals, and increase weight loss in a rodent model of gastric bypass, suggesting that premenopausal women may lose more weight following bariatric surgery.

Methods

One thousand three hundred fifty-six female gastric-bypass or gastric-banding patients were retrospectively grouped as 20–45 years old (presumptively premenopausal; n = 1,199) and 55–65 years old (presumptively postmenopausal; n = 157). Mixed-model ANCOVA followed by Bonferroni-corrected t tests were used to categorically test the effect of age on percent excess body weight loss (%EBWL) at 1 and 2 years post-surgery, controlling for preoperative EBW and surgery type. Age effects were also tested dimensionally in all women and in 289 male patients.

Results

Twenty- to forty-five-year-old women showed greater %EBWL 1 and 2 years post-surgery than 55–65-year-old women (p’s < 0.0005). No age effect was detected in 20–25- vs. 30–35-, 30–35- vs. 40–45-, or 20–25- vs. 40–45-year-old women (p’s > 0.2) This age effect was detected only after gastric banding, with 20–45-year-old women losing ∼7 kg more than 55–65-year-old women after 2 years. Dimensional analysis confirmed a significant inverse effect of age on bariatric surgery outcome in women, but did not detect any effect in men.

Conclusions

Results indicate that 55–65-year-old women lose less weight than 20–45-year-old women in the initial 2 years after bariatric surgery, especially gastric banding; this may be mediated by age- or menopause-associated changes in physical activity, energy expenditure, or energy intake.

Keywords

Estrogen Menopause Gastric bypass Gastric banding RYGB 

Notes

Conflict of Interest Disclosures

Christopher Ochner, PhD: no conflict of interest

Julio Teixeira, MD: no conflict of interest

Nori Geary, PhD: no conflict of interest

Lori Asarian, PhD: no conflict of interest

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Christopher N. Ochner
    • 1
    • 2
    • 6
  • Julio Teixeira
    • 3
  • Nori Geary
    • 4
  • Lori Asarian
    • 5
  1. 1.Department of PsychiatryColumbia University College of Physicians and SurgeonsNew YorkUSA
  2. 2.New York Obesity Nutrition Research CenterSt. Luke’s-Roosevelt Hospital CenterNew YorkUSA
  3. 3.Center for Weight Loss Surgery, Department of Minimally Invasive Surgery, St. Luke’s-Roosevelt Hospital CenterColumbia University College of Physicians and SurgeonsNew YorkUSA
  4. 4.SchwerzenbachSwitzerland
  5. 5.Institute of Veterinary Physiology, Vetsuisse FacultyUniversity of ZurichZurichSwitzerland
  6. 6.NY Obesity Research CenterSt. Luke’s-Roosevelt Hospital CenterNew YorkUSA

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