Roux en Y Gastric Bypass Increases Ethanol Intake in the Rat
- 449 Downloads
Roux en Y gastric bypass (RYGB) surgery is currently the most effective therapy employed to treat obesity and its associated complications. In addition to weight loss and resolution of metabolic syndromes, such as diabetes, the RYGB procedure has been reported to increase alcohol consumption in humans. Using an outbred rodent model, we demonstrate that RYGB increases postsurgical ethanol consumption, that this effect cannot be explained solely by postsurgical weight loss and that it is independent of presurgical body weight or dietary composition. Altered ethanol metabolism and postsurgical shifts in release of ghrelin were also unable to account for changes in alcohol intake. Further investigation of the potential physiological factors underlying this behavioral effect identified altered patterns of gene expression in brain regions associated with reward following RYGB surgery. These findings have important clinical implications as they demonstrate that RYGB surgery leads directly to increased alcohol intake in otherwise alcohol nonpreferring rat and induces neurobiological changes in brain circuits that mediate a variety of appetitive behaviors.
KeywordsRoux en Y gastric bypass Ethanol Orexin Dopamine
This work was funded by a private research grant from Ethicon Endo-Surgery Inc.
- 27.Barazzoni R, Zanetti M, Nagliati C, et al. Gastric bypass does not normalize obesity-related changes in ghrelin profile and leads to higher acylated ghrelin fraction. Obesity. 2012. doi: 10.1038/oby.2012.149.
- 28.Chambers AP, Kirchner H, Wilson-Perez HE, et al. The effects of vertical sleeve gastrectomy in rodents are ghrelin independent. Gastroenterology. 2013. doi: 10.1053/j.gastro.2012.09.009.
- 29.Kurose T, Ueta Y, Yamamoto Y, et al. Effects of restricted feeding on the activity of hypothalamic orexin (OX)-A containing neurons and OX2 receptor mRNA in the paraventricular nucleus of rats. Regul Pept. 2002;104(1–3):141–5.Google Scholar
- 48.Wiederman MW, Pryor T. Substance use among women with eating disorders. Int J Eat Disord. 1996;20:163–8. doi: 10.1002/(SICI)1098-108X(199609)20:2_163::AID-EAT6_3.0.CO;2-E.PubMedCrossRefGoogle Scholar
- 53.Sarwer D, Fabricatore A, Jones-Corneille L, et al. Psychological issues following bariatric surgery. Primary Psychiatry. 2008;8:50–5.Google Scholar
- 54.Abbey A, Smith M. Psychosocial factors that influence American adults alcohol consumption. Drug Alcohol Abuse Rev. 1992;3:1–31.Google Scholar