Obesity Surgery

, Volume 23, Issue 4, pp 554–560 | Cite as

Fibronectin Gene Expression in Human Adipose Tissue and Its Associations with Obesity-Related Genes and Metabolic Parameters

  • Seoung Hee Lee
  • Hye Soon Park
  • Jung Ah Lee
  • Young Sook Song
  • Yeon Jin Jang
  • Jong-Hyeok Kim
  • Yeon Ji Lee
  • Yoonseok Heo
Clinical Research



Limited data are available on the in vivo expression of fibronectin, one of the main extracellular matrix components. We investigated the expression of fibronectin in abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) and the associations of leptin, adiponectin, and vaspin gene expression with metabolic parameters in obese women.


We recruited female subjects undergoing bariatric surgery for obesity (n = 24) and patients undergoing benign gynecological surgery as the control group (n = 23). We measured anthropometric variables, abdominal fat distribution, metabolic parameters, serum concentrations of leptin, adiponectin, and vaspin, and depot-specific mRNA expression of fibronectin, leptin, adiponectin, and vaspin.


Fibronectin expression in both VAT and SAT was significantly lower in the obese group than in the control group. Fibronectin expression in both VAT and SAT were negatively correlated with body mass index or waist circumference, with higher prominence in VAT. In multiple regression analysis, fibronectin expression in both VAT and SAT was negatively correlated with serum leptin concentration. Fibronectin expression in VAT was negatively correlated with leptin expression in VAT. Additionally, fibronectin expression in SAT was negatively correlated with leptin expression in SAT and positively correlated with adiponectin expression in VAT and SAT.


We found significant negative associations between depot-specific fibronectin expression in human adipose tissue and obesity indices and obesity-related biomarkers. Our results suggest that fibronectin expression may contribute to obesity and metabolic dysregulation in humans.


Obesity Adipose tissue Fibronectin Leptin Adiponectin 


Conflict of Interest

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (2012–004869) Seoul, Korea. Seoung Hee Lee, Hye Soon Park, Jung Ah Lee, Young Sook Song, Yeon Jin Jang, Jong-Hyeok Kim, Yeon Ji Lee, Yoonseok Heo declare that they have no conflicts of interest.


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Seoung Hee Lee
    • 1
  • Hye Soon Park
    • 1
  • Jung Ah Lee
    • 1
  • Young Sook Song
    • 2
  • Yeon Jin Jang
    • 2
  • Jong-Hyeok Kim
    • 3
  • Yeon Ji Lee
    • 4
  • Yoonseok Heo
    • 5
  1. 1.Department of Family MedicineUniversity of Ulsan College of MedicineSeoulSouth Korea
  2. 2.Department of PhysiologyUniversity of Ulsan College of MedicineSeoulSouth Korea
  3. 3.Department of Obstetrics and GynecologyUniversity of Ulsan College of MedicineSeoulSouth Korea
  4. 4.Department of Family MedicineInha University, College of MedicineIncheonSouth Korea
  5. 5.Department of General SurgeryInha University, College of MedicineIncheonSouth Korea

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