Obesity Surgery

, Volume 22, Issue 11, pp 1742–1745

Ghrelin Level and Weight Loss After Laparoscopic Sleeve Gastrectomy and Gastric Mini-Bypass for Prader–Willi Syndrome in Chinese

  • Anthony K. W. Fong
  • Simon K. H. Wong
  • Candice C. H. Lam
  • Enders K. W. Ng
Clinical Report

Abstract

Prader–Willi syndrome (PWS) is a chromosomal disorder characterized by the presence of hyperghrelinemia, hyperphagia, and obesity. The optimal treatment for PWS patient remains controversial. Here, we present our experience of treating PWS with laparoscopic mini-gastric bypass (LMGBP) and laparoscopic sleeve gastrectomy (LSG). Three patients with genetic diagnosis of PWS and body mass index (BMI) greater than 40 kg/m2 were referred for bariatric surgery. All of them had completed 2-year postoperative follow-up. Body weight, BMI, and ghrelin levels were recorded before and after surgery. They were two females and one male. Their age ranged from 15 to 23 years old, and the mean BMI was 46.7 kg/m2 (range 44–50). Two patients underwent LSG and one patient underwent LMGBP. After a median follow-up of 33 months (range 24–36 months), mean weight loss and percentage of excessive weight loss at 2 years were 32.5 kg (24.9–38.3 kg) and 63.2 % (range 50.5–86.2 %), respectively. The mean fasting active ghrelin level decreased from 1,134.2 pg/ml preoperatively to 519.8 pg/ml 1 year after surgery. No major complication was observed. Iron deficiency anemia was observed in the patient who underwent LMGBP. Significant reduction of body weight and level of serum ghrelin can be achieved with minimal morbidity by LSG or LMGBP in patients with PWS.

Keywords

Bariatric surgery Prader–Willi syndrome Laparoscopy Ghrelin 

Copyright information

© Springer Science + Business Media, LLC 2012

Authors and Affiliations

  • Anthony K. W. Fong
    • 1
  • Simon K. H. Wong
    • 1
  • Candice C. H. Lam
    • 1
  • Enders K. W. Ng
    • 1
  1. 1.Division of Upper GI Surgery, Department of Surgery, Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina

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