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Obesity Surgery

, Volume 22, Issue 6, pp 950–955 | Cite as

Obesity and Inflammation: Change in Adiponectin, C-Reactive Protein, Tumour Necrosis Factor-Alpha and Interleukin-6 After Bariatric Surgery

  • Fátima Illán-GómezEmail author
  • Manuel Gonzálvez-Ortega
  • Isabel Orea-Soler
  • Ma. Soledad Alcaraz-Tafalla
  • Aurora Aragón-Alonso
  • Mercedes Pascual-Díaz
  • Matías Pérez-Paredes
  • Ma. Luisa Lozano-Almela
Clinical Research

Abstract

Background

Obesity is associated with a low-grade inflammatory state. A causal association between inflammation and atherosclerosis has been suggested. The aim of this study was to evaluate changes in the proinflammatory profile of morbidly obese patients after weight loss following bariatric surgery.

Methods

In this study, we measured levels of adiponectin, high-sensitivity C-reactive protein (hs-CRP), tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) and their relation to insulin resistance and lipid parameters in 60 morbidly obese women at baseline and 3, 6 and 12 months after gastric bypass.

Results

Twelve months after surgery, there was a significant increase in plasma levels of adiponectin (p < 0.001) and high-density lipoprotein cholesterol (p < 0.01) and a significant decrease in levels of IL-6 (p < 0.001), hs-CRP (p < 0.001), cholesterol (p < 0.001), triglycerides (p < 0.001), low-density lipoprotein cholesterol (p < 0.001), glucose (p < 0.001), insulin (p < 0.001) and homeostasis model assessment (HOMA; p < 0.001). At 12 months, correlations were seen between IL-6 levels and the following: body mass index (BMI) (r = 0.53, p < 0.001), insulin (r = 0.51, p < 0.001) and HOMA (r = 0.55, p < 0.001). Also, hs-CRP levels correlated with BMI (r = 0.40, p = 0. 004), triglycerides (r = 0.34, p = 0.017), insulin (r = 0.50, p = 0.001) and HOMA (r = 0.46, p = 0.002).

Conclusions

In patients with morbid obesity, significant weight loss is followed by a significant improvement in the inflammatory state, insulin sensitivity and lipid profile. A relationship exists between improved inflammatory profile and insulin sensitivity.

Keywords

Obesity Bariatric surgery Adiponectin TNF-α IL-6 hs-CRP Inflammation Insulin resistance 

Notes

Conflict of interest

Fátima Illán Gómez, Manuel Gonzálvez Ortega, Isabel Orea Soler, Ma. Soledad Alcaraz Tafalla, Aurora Aragón Alonso, Mercedes Pascual Díaz, Matías Pérez Paredes, Ma. Luisa Lozano Almela declare that they have no conflicts of interest.

Supplementary material

11695_2012_643_MOESM1_ESM.pdf (511 kb)
ESM 1 (PDF 510 kb)

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Copyright information

© Springer Science + Business Media, LLC 2012

Authors and Affiliations

  • Fátima Illán-Gómez
    • 1
    Email author
  • Manuel Gonzálvez-Ortega
    • 2
  • Isabel Orea-Soler
    • 1
  • Ma. Soledad Alcaraz-Tafalla
    • 1
  • Aurora Aragón-Alonso
    • 1
  • Mercedes Pascual-Díaz
    • 1
  • Matías Pérez-Paredes
    • 2
  • Ma. Luisa Lozano-Almela
    • 3
  1. 1.Department of Endocrinology and NutritionUniversity Hospital Morales MeseguerMurciaSpain
  2. 2.Department of CardiologyUniversity Hospital Morales MeseguerMurciaSpain
  3. 3.Department of HematologyUniversity Hospital Morales MeseguerMurciaSpain

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