Obesity Surgery

, Volume 22, Issue 7, pp 1016–1021 | Cite as

Improvement of Nonalcoholic Fatty Liver Disease After Bariatric Surgery in Morbidly Obese Chinese Patients

  • Chi-Ming Tai
  • Chih-Kun Huang
  • Jau-Chung Hwang
  • Hung Chiang
  • Chi-Yang Chang
  • Ching-Tai Lee
  • Ming-Lung Yu
  • Jaw-Town Lin
Clinical Research



Obesity is a risk factor for nonalcoholic fatty liver disease (NAFLD), which appears to improve after weight loss induced by bariatric surgery in Western countries. The present study aims to determine the alterations of clinical measurements and liver histology of NAFLD after bariatric surgery in morbidly obese Chinese patients.


Between November 2006 and December 2007, 21 morbidly obese patients receiving intra-operative liver biopsy and follow-up liver biopsy 1 year after laparoscopic Roux-en-Y gastric bypass were enrolled. NAFLD activity score (NAS) and fibrosis stage were histologically evaluated.


The mean body mass index fell from 43.8 ± 7.5 to 28.3 ± 4.6 kg/m2 (P < 0.01). Biochemical improvement was found in serum levels of alanine aminotransferase (P < 0.01) and γ-glutamyltransferase (P < 0.01), but not aspartate aminotransferase (P = 0.66). Histological improvement was noted in NAS (P < 0.01) and individual components, including steatosis (P < 0.01), ballooning degeneration (P < 0.01), and lobular inflammation (P = 0.02). Pre-operatively, 4 (19.0%), 11 (52.4%), and 6 (28.6%) patients were found to have NAS ≧5, 3 or 4, and ≦2, respectively. All patients had NAS ≦2 after surgery. Fibrosis stage also showed significant improvement (P < 0.01).


Bariatric surgery can achieve a dramatic improvement of NAFLD both biochemically and histologically in morbidly obese Chinese patients.


Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Obesity Bariatric surgery Liver biopsy 



Nonalcoholic fatty liver disease


Nonalcoholic steatohepatitis


Roux-en-Y gastric bypass


NAFLD activity score


Body mass index


Laparoscopic Roux-en-Y gastric bypass


Waist circumference


Aspartate aminotransferase


Alanine aminotransferase




High-density lipoprotein


Low-density lipoprotein


Homeostatic model assessment


Standard deviation



This study was supported by a project of the E-Da Hospital, grant number EDAHP-98-015.


The authors declare no conflict of interest.


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Copyright information

© Springer Science + Business Media, LLC 2011

Authors and Affiliations

  • Chi-Ming Tai
    • 1
    • 2
  • Chih-Kun Huang
    • 3
  • Jau-Chung Hwang
    • 4
  • Hung Chiang
    • 5
  • Chi-Yang Chang
    • 1
  • Ching-Tai Lee
    • 1
  • Ming-Lung Yu
    • 6
  • Jaw-Town Lin
    • 1
    • 7
  1. 1.Department of Internal Medicine, E-Da HospitalI-Shou UniversityKaohsiungTaiwan
  2. 2.Institute of Clinical Medicine, College of MedicineKaohsiung Medical UniversityKaohsiungTaiwan
  3. 3.Department of Surgery, E-Da HospitalI-Shou UniversityKaohsiungTaiwan
  4. 4.Department of Pathology, E-Da HospitalI-Shou UniversityKaohsiungTaiwan
  5. 5.Department of Anatomic PathologyTaipei Institute of PathologyTaipeiTaiwan
  6. 6.Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiungTaiwan
  7. 7.Department of Internal Medicine, National Taiwan University HospitalNational Taiwan UniversityTaipeiTaiwan

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