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Obesity Surgery

, Volume 22, Issue 7, pp 1044–1049 | Cite as

Effect of Bariatric Surgery on Liver Fibrosis

  • Myriam Moretto
  • Carlos Kupski
  • Vinicius Duval da Silva
  • Alexandre V. Padoin
  • Cláudio C. Mottin
Clinical Research

Abstract

Background

Although bariatric surgery has been shown to improve hepatic steatosis in morbidly obese patients, the effect of weight loss on hepatic fibrosis has not been determined. Since the prognosis of patients with nonalcoholic fatty liver disease is closely related to the development of hepatic fibrosis, it is important to determine the hepatic histology of these patients after weight loss. We therefore evaluated the prevalence of hepatic fibrosis in morbidly obese patients undergoing bariatric surgery and assessed the correlation of histologic changes with weight loss.

Methods

We retrospectively evaluated 78 morbidly obese patients who underwent gastric bypass. Liver biopsies were taken during surgery and after weight loss, and the correlations between histologic findings and hepatic fibrosis were determined.

Results

Of the 78 patients, 35 (44.8%) had fibrosis at first biopsy, and 24 (30.8%) had hepatic fibrosis after weight loss, including 19 of the 35 patients (54.3%) with fibrosis at first biopsy and 5 of the 43 (11.6%) without hepatic fibrosis at first biopsy (P = 0.027).

Conclusions

Weight loss in morbidly obese patients was associated with a reduction in the prevalence of hepatic fibrosis.

Keywords

Liver fibrosis Cirrhosis Morbid obesity Bariatric surgery Nonalcoholic steatohepatitis 

Notes

Conflict of Interest

None of the authors has any conflicts of interest to declare.

Disclosure

No external funding supported this work. None of the authors has any financial interest to declare.

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Copyright information

© Springer Science + Business Media, LLC 2011

Authors and Affiliations

  • Myriam Moretto
    • 1
  • Carlos Kupski
    • 1
  • Vinicius Duval da Silva
    • 1
  • Alexandre V. Padoin
    • 1
  • Cláudio C. Mottin
    • 1
  1. 1.Centro da Obesidade e Síndrome Metabólica do Hospital São LucasPontifícia Universidade Católica do Rio Grande do SulPorto AlegreBrazil

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