Obesity Surgery

, Volume 21, Issue 9, pp 1444–1450

Reversible Gastric Restriction Implant: Safety and Efficacy in a Canine Model

  • Xiaomei Guo
  • Hai Zheng
  • Samer G. Mattar
  • Xiao Lu
  • George Sandusky
  • Jose A. Navia
  • Ghassan Kassab
Animal Research

Abstract

Background

Gastric restrictive procedures are considered effective weight loss treatment for severe obesity. The aim of the study was to evaluate the efficacy and safety of a reversible implant that renders a partial restriction of stomach in a canine model.

Methods

The device was comprised of two longitudinal parallel non-compressive plates with two C-rings to create a small gastric pouch that opposed gastric distension. Three groups of non-obese mongrel dogs were included: group I (n = 6) underwent surgical implant for 6 weeks, group II (n = 6) underwent surgical implant for 6 weeks, followed by surgical removal of the implant and additional monitoring for 5 weeks, and group III (n = 5) served as sham-operated controls for groups I and II. Food intake and body weight were monitored, and the stomachs were examined histologically postmortem.

Results

The average food intake was significantly decreased by 38.2% in group I as compared to group III throughout the 6 weeks of surgical implant (P < 0.05). The implanted dogs showed a progressive weight loss as compared to sham, which reached 21% by the end of 6 weeks. In group II, after 5 weeks of implant removal, the body weights recovered to approximately 96% of baseline. Histological evidence of the implant site at the gastric walls revealed no significant structural changes, tissue ischemia, hemorrhage, or necrosis.

Conclusion

Our results validate the feasibility of a reversible gastric restriction implant in a non-obese canine model, with the potential for achieving significant weight loss within 6 weeks and with no injury to the gastric wall.

Keywords

Obesity Restrictive procedure Implant Food intake Body weight 

Copyright information

© Springer Science + Business Media, LLC 2010

Authors and Affiliations

  • Xiaomei Guo
    • 1
  • Hai Zheng
    • 1
  • Samer G. Mattar
    • 2
  • Xiao Lu
    • 1
  • George Sandusky
    • 3
  • Jose A. Navia
    • 4
  • Ghassan Kassab
    • 1
    • 2
    • 5
  1. 1.Department of Biomedical EngineeringIndiana University–Purdue University IndianapolisIndianapolisUSA
  2. 2.Department of SurgeryIUPUIIndianapolisUSA
  3. 3.Department of PathologyIUPUIIndianapolisUSA
  4. 4.Department of SurgeryAustral UniversityBuenos AiresArgentina
  5. 5.Cellular and Integrative PhysiologyIUPUIIndianapolisUSA

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