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Single vs Repeated Treatment with the Intragastric Balloon: A 5-Year Weight Loss Study

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Abstract

Background

Saline-filled intragastric balloons (IB) may be inserted for 6 months to promote weight loss. We aimed to assess potential benefits of repeating IB therapy.

Methods

One hundred eighteen consecutive subjects (median body mass index, 34.0 kg/m2; interquartile range [IQR], 31.2–36.9) treated with IB were included in a prospective non-randomized multicenter study.

Results

Nineteen (16%) subjects had repeat IB therapy at their own request, either to prolong first treatment (n = 8) or after a IB-free interval (n = 11). Higher weight loss 3 months after first IB insertion independently predicted repeat therapy (P = 0.008). Median weight loss in subjects who had repeat therapy was lower with second vs first IB (9.0 vs 14.6 kg; 30.4% vs 49.3% excess weight [EW]; P = 0.003). Compared to subjects with single treatment (n = 99), those with repeat treatment (n = 19) had greater weight loss at first IB extraction (14.6 vs 11.0 kg; 49.3% vs 30.7% EW; P = 0.026) and 1 year later (12.0 vs 6.0 kg; 40.9% vs 20.8% EW; P = 0.008) but the difference became less than 2 kg starting at 3 years. At final follow-up (4.9 years; IQR, 3.4–6.7), the whole subject population had lost a median of 2.0 kg (IQR, −3.0 to 10.3) or 6.2% EW (IQR, −8.1 to 31.6) and identical proportions of subjects with single/repeat treatment had ≥10% baseline weight loss (26%) or bariatric surgery (32%).

Conclusion

Higher weight loss at 3 months independently predicted repeat IB therapy; weight loss with the second IB was lower compared to first IB. Repeat treatment had no effect on proportions of subjects with ≥10% baseline weight loss or bariatric surgery at final follow-up.

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Abbreviations

BMI:

body mass index

IB:

intragastric balloon

IQR:

interquartile range

LOCF:

last observation carried forward

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Potential Conflicts of Interests

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Service of Gastroenterology and Hepatology, Geneva University Hospitals, Micheli-du-Crest street 24, 1205, Geneva, Switzerland

    Jean-Marc Dumonceau

  2. Department of Gastroenterology and Hepato-Pancreatology, Erasme University Hospital, Lennikstreet 808, 1070, Brussels, Belgium

    Erik François, Axel Hittelet, Marie Barea & Jacques Deviere

  3. Department of Digestive Surgery, Erasme University Hospital, Lennikstreet 808, 1070, Brussels, Belgium

    Abdel Ilah Mehdi

  4. Division of Gastroenterology and Hepatology, Geneva University Hospitals, Micheli-du-Crest street 24, 1205, Geneva, Switzerland

    Jean-Marc Dumonceau

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  1. Jean-Marc Dumonceau
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  2. Erik François
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  3. Axel Hittelet
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  4. Abdel Ilah Mehdi
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  5. Marie Barea
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  6. Jacques Deviere
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Correspondence to Jean-Marc Dumonceau.

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Dumonceau, JM., François, E., Hittelet, A. et al. Single vs Repeated Treatment with the Intragastric Balloon: A 5-Year Weight Loss Study. OBES SURG 20, 692–697 (2010). https://doi.org/10.1007/s11695-010-0127-x

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