Obesity Surgery

, Volume 20, Issue 6, pp 685–691

A Noninvasive Clinical Scoring Model Predicts Risk of Nonalcoholic Steatohepatitis in Morbidly Obese Patients

  • Alex Ulitsky
  • Ashwin N. Ananthakrishnan
  • Richard Komorowski
  • James Wallace
  • Sri Naveen Surapaneni
  • Jose Franco
  • Kia Saeian
  • Samer Gawrieh
Clinical Research

DOI: 10.1007/s11695-010-0118-y

Cite this article as:
Ulitsky, A., Ananthakrishnan, A.N., Komorowski, R. et al. OBES SURG (2010) 20: 685. doi:10.1007/s11695-010-0118-y

Abstract

Background

A simple model to predict nonalcoholic steatohepatitis (NASH) in patients with nonalcoholic fatty liver disease is desirable to optimize the selection of patients for liver biopsy. We investigated a large group of morbidly obese patients to derive a scoring system based on simple clinical and laboratory variables.

Methods

Consecutive subjects undergoing bariatric surgery and without evidence of other liver disease or significant alcohol use underwent intraoperative liver biopsy. Demographic, clinical, and biochemical variables were collected. A scoring model was derived using variables found to be independent predictors of NASH. The scores were divided into four risk categories (low, intermediate, high, and very high). Positive and negative predictive values (PPV/NPV) were derived for each category and the area under the receiver operator curve (AUROC) was calculated.

Results

A total of 253 subjects were included: 52 (20.6%) had NASH, 116 (45.8%) had simple steatosis, and 85 (33.6%) had normal liver histology. Only ten subjects (19% of NASH group) had significant (≥ stage 2) fibrosis. Multivariate analysis identified diabetes, abnormal ALT, and hypertriglyceridemia as independent predictors of NASH. Sleep apnea showed a strong trend toward significance and was also included in the model. This model showed a NPV of 89.7% in the low risk category and a PPV of 75% in the very high risk category, with AUROC of 0.76.

Conclusions

A simple scoring system performs well in predicting NASH and can be used in the clinic to optimize the selection of morbidly obese patients for liver biopsy.

Keywords

NASH Morbid obesity Predictive model Liver biopsy NAFLD Hepatosteatosis 

Copyright information

© Springer Science + Business Media, LLC 2010

Authors and Affiliations

  • Alex Ulitsky
    • 4
  • Ashwin N. Ananthakrishnan
    • 4
  • Richard Komorowski
    • 1
  • James Wallace
    • 2
  • Sri Naveen Surapaneni
    • 4
  • Jose Franco
    • 4
  • Kia Saeian
    • 4
  • Samer Gawrieh
    • 4
    • 3
  1. 1.Division of Surgical Pathology, Department of PathologyMedial College of WisconsinMilwaukeeUSA
  2. 2.Department of SurgeryMedial College of WisconsinMilwaukeeUSA
  3. 3.Zabocki VA Medical CenterMilwaukeeUSA
  4. 4.Division of Gastroenterology and Hepatology, Department of MedicineMedical College of WisconsinMilwaukeeUSA

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