Obesity Surgery

, Volume 19, Issue 8, pp 1132–1138 | Cite as

Increase of Bone Resorption and the Parathyroid Hormone in Postmenopausal Women in the Long-term after Roux-en-Y Gastric Bypass

  • Juan P. ValderasEmail author
  • Soledad Velasco
  • Sandra Solari
  • Yessica Liberona
  • Paola Viviani
  • Alberto Maiz
  • Alex Escalona
  • Gilberto González
Research Clinical



The effects of Roux-en-Y Gastric Bypass (RYGB) on bone in the long-term remains unclear. We assessed bone metabolism and bone mineral density (BMD) 1 to 5 years after RYGB.


We designed a retrospective cohort study in 26 postmenopausal women (58.0 ± 3.9 years old) with RYGB 3.5 ± 1.1 years before (body mass index (BMI) 29.5 ± 3.8 kg/m2, presurgery 43.6 ± 5.5 kg/m2) and 26 nonoperated women (57.5 ± 4.7 years old, BMI 29.2 ± 4.1 kg/m2) matched by age and BMI. The main measures were BMD, serum carboxy telopeptide (CTx), total alkaline phosphatases (ALP), parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), and ghrelin.


RYGB group, compared to nonoperated women, had higher CTx (0.71 ± 0.21 vs. 0.43 ± 0.15 ng/ml; P < 0.01) and PTH (68.3 ± 35 vs. 49.4 ± 16 pg/ml; P = 0.02). There were no differences between RYGB and nonoperated women in: calcium and vitamin D intake (759 ± 457 vs. 705 ± 460 mg/day; 176 ± 160 vs. 111 ± 86 UI/day), ghrelin (763 ± 336 vs. 621 ± 274 pg/ml), ALP (101 ± 22 vs. 94 ± 25 UI/l), 25OHD (18.8  ± 7.6 vs. 17.4 ± 5.9 ng/ml), lumbar spine BMD (1.059 ± 0.32 vs. 1.071 ± 0.207 g/cm2), or femoral neck BMD (0.892 ± 0.109 vs. 0.934 ± 1.1 g/cm2).


RYGB is associated to high bone resorption and hyperparathyroidism prevalence in postmenopausal women in the long-term. This occurs independently of the intake of calcium, vitamin D status, or ghrelin and does not seem to affect BMD after RYGB.


Bariatric surgery Gastric bypass Hyperparathyroidism Bone Obesity Menopause 



This study was supported by funds from the Department of Nutrition, Diabetes, and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile. We would like to thank Ms. Susan Smalley M. for her critical review in English of our manuscript and to Ms. Jacqueline Parada for the CTx measurements.

Disclosure statement

The authors have nothing to disclose.


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Copyright information

© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Juan P. Valderas
    • 1
    Email author
  • Soledad Velasco
    • 2
  • Sandra Solari
    • 3
  • Yessica Liberona
    • 1
  • Paola Viviani
    • 5
  • Alberto Maiz
    • 1
  • Alex Escalona
    • 4
  • Gilberto González
    • 2
  1. 1.Department of Nutrition, Diabetes, and Metabolism, Faculty of MedicinePontificia Universidad Católica de ChileSantiagoChile
  2. 2.Department of Endocrinology, Faculty of MedicinePontificia Universidad Católica de ChileSantiagoChile
  3. 3.Department of Clinical Laboratory, Faculty of MedicinePontificia Universidad Católica de ChileSantiagoChile
  4. 4.Department of Digestive Surgery, Faculty of MedicinePontificia Universidad Católica de ChileSantiagoChile
  5. 5.Department of Public Health, Faculty of MedicinePontificia Universidad Católica de ChileSantiagoChile

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