Obesity Surgery

, Volume 19, Issue 9, pp 1256–1261 | Cite as

Comparison of the Absorption of Calcium Carbonate and Calcium Citrate after Roux-en-Y Gastric Bypass

  • P. Tondapu
  • D. Provost
  • B. Adams-Huet
  • T. Sims
  • C. Chang
  • K. Sakhaee
Clinical Report

Abstract

Introduction

Roux-en-Y gastric bypass (RYGB) restricts food intake. Consequently, patients consume less calcium. In addition, food no longer passes through the duodenum, the main site of calcium absorption. Therefore, calcium absorption is significantly impaired. The goal of this study is to compare two common calcium supplements in gastric bypass patients.

Method

Nineteen patients were enrolled in a randomized, double-blinded, crossover study comparing the absorption of calcium from calcium carbonate and calcium citrate salts. Serum and urine calcium levels were assessed for peak values (C max) and cumulative calcium increment (area under the curve [AUC]). Serum PTH was assessed for minimum values (PTHmin) and cumulative PTH decrement (AUC). Statistical analysis was performed using a repeated analysis of variance model.

Results

Eighteen subjects completed the study. Calcium citrate resulted in a significantly higher serum C max (9.4 + 0.4 mg/dl vs. 9.2 + 0.3 mg/dl, p = 0.02) and serum AUC (55 + 2 mg/dl vs. 54 + 2 mg/dl, p = 0.02). Calcium citrate resulted in a significantly lower PTHmin (24 + 11 pg/ml vs. 30 + 13 pg/ml, p = 0.01) and a higher AUC (−32 + 51 pg/ml vs. −3 + 56 pg/ml, p = 0.04). There was a non-significant trend for higher urinary AUC in the calcium citrate group (76.13 + 36.39 mg/6 h vs. 66.04 + 40.82, p = 0.17).

Conclusion

Calcium citrate has superior bioavailability than calcium carbonate in RYGB patients.

Keywords

Roux-en-Y gastric bypass Obesity Calcium citrate Calcium carbonate 

Notes

Acknowledgments

This work was supported by the National Institute of Health (NIH) grants MO1-RR00633 and CTSA UL1-RR024982. The authors would like to acknowledge the editorial assistance of Ms. Hadley Armstrong.

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Copyright information

© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • P. Tondapu
    • 1
  • D. Provost
    • 3
  • B. Adams-Huet
    • 2
  • T. Sims
    • 1
  • C. Chang
    • 4
  • K. Sakhaee
    • 1
  1. 1.Department of Internal Medicine, Charles and Jane Pak Center for Mineral MetabolismUT Southwestern Medical CenterDallasUSA
  2. 2.Division of Biostatistics, Department of Clinical SciencesUT Southwestern Medical CenterDallasUSA
  3. 3.Provost BariatricsDentonUSA
  4. 4.Citizens Bariatric CenterVictoriaUSA

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