Obesity Surgery

, Volume 19, Issue 5, pp 608–616

Lipoprotein Lipase Expression in Livers of Morbidly Obese Patients Could be Responsible for Liver Steatosis

  • Eva Pardina
  • Juan A. Baena-Fustegueras
  • Rafael Llamas
  • Roberto Catalán
  • Rosa Galard
  • Albert Lecube
  • Jose M. Fort
  • Miquel Llobera
  • Helena Allende
  • Víctor Vargas
  • Julia Peinado-Onsurbe
Clinical Research
  • 263 Downloads

Abstract

Background

Most patients with morbid obesity develop non-alcoholic fatty liver disease (NAFLD). The origins of lipid deposition in the liver and the effects of bariatric surgery in the obese with NAFLD are controversial.

Methods

We analyzed lipids and lipoprotein lipase (LPL) in both plasma and liver biopsies performed before and 12–18 months after Roux-en-Y gastric bypass surgery in 26 patients.

Results

In the livers of morbidly obese patients, the levels of LPL messenger RNA (mRNA) were higher (4.5-fold) before surgery than afterwards than control livers. In these patients, LPL activity was also significantly higher (91 ± 7 mU/g) than in controls (51 ± 3 mU/g, p = 0.0026) and correlated with the severity of the liver damage. All hepatic lipids were significantly increased in obese patients; however, after bariatric surgery, these lipids, with the exception of NEFA, tended to recover to normal levels.

Conclusions

The liver of obese patients presented higher LPL activity than controls, and unlike the controls, this enzyme could be synthesized in the liver because it also present LPL mRNA. The presence of the LPL activity could enable the liver to capture circulating triacylglycerides, thus favoring the typical steatosis observed in these patients.

Keywords

Metabolic syndrome Hepatic steatosis NAFLD NASH LPL 

Abbreviations

NAFLD

non-alcoholic fatty liver disease

LPL

lipoprotein lipase

FFA

free fatty acids

ALT

alanine aminotransferase

AST

aspartate aminotransferase

HOMA-IR

homeostasis model assessment of insulin resistance

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Copyright information

© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Eva Pardina
    • 1
  • Juan A. Baena-Fustegueras
    • 2
    • 3
  • Rafael Llamas
    • 1
  • Roberto Catalán
    • 2
    • 4
  • Rosa Galard
    • 2
    • 4
  • Albert Lecube
    • 2
    • 5
  • Jose M. Fort
    • 2
    • 3
  • Miquel Llobera
    • 1
  • Helena Allende
    • 2
    • 6
  • Víctor Vargas
    • 2
    • 6
  • Julia Peinado-Onsurbe
    • 1
  1. 1.Biochemistry and Molecular Biology Department, Biology FacultyBarcelona UniversityBarcelonaSpain
  2. 2.Institut de Recerca Vall D’HebronUniversitat Autònoma De BarcelonaBarcelonaSpain
  3. 3.Endocrinology Surgery UnitInstituto de Salud Carlos III (ISCIII)MadridSpain
  4. 4.Biochemistry DepartmentInstituto de Salud Carlos III (ISCIII)MadridSpain
  5. 5.Diabetes Research Unit, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)Instituto de Salud Carlos III (ISCIII)MadridSpain
  6. 6.CIBER de Enfermedades Hepáticas y Digestivas (CIBERHED)Instituto de Salud Carlos III (ISCIII)MadridSpain

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