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Obesity Surgery

, Volume 19, Issue 5, pp 655–660 | Cite as

Rat Models for Bariatric Surgery and Surgery for Type 2 Diabetes Mellitus

  • Sheetal Bharat Mistry
  • Juan J. Omana
  • Subhash KiniEmail author
Review

Abstract

Type 2 diabetes mellitus being one of the most prevalent diseases in the world has led to a variety of research using animal models. This review focuses on various rat models to study the effect that surgical procedures have on type 2 diabetes mellitus and obesity. Rat models can be classified as Obese Diabetic, Non-Obese Diabetic, Obese Non-Diabetic, and Non-Obese Non-Diabetic. Here, we have discussed the particular characteristics of each rat so that it can provide the appropriate model to study different pathological processes involve in type 2 Diabetes and obesity.

Keywords

Rat models Bariatric surgery Type 2 diabetes mellitus Obesity Insulin resistance Hyperglycemia Weight loss Zucker diabetic fatty (ZDF) Spontaneously hypertensive rat/National Institute of Health corpulent (SHR/N-cp) James C. Russell/LA corpulent (JCR/LA-cp) Otsuka Long–Evans Tokushima Fatty (OLETF) Goto–Kakizaki (GK) Cohen rat Torri rat Wistar rat Sprague–Dawley rat Zucker fatty (ZF) 

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Copyright information

© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Sheetal Bharat Mistry
    • 1
  • Juan J. Omana
    • 2
  • Subhash Kini
    • 2
    Email author
  1. 1.606/B Kalpataru ClassicMaharashtraIndia
  2. 2.Department SurgeryMount Sinai School of MedicineNew YorkUSA

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