Ghrelin and Apolipoprotein AIV Levels Show Opposite Trends to Leptin Levels During Weight Loss in Morbidly Obese Patients
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Although bariatric surgery is the most common procedure used to induce weight loss in morbidly obese patients, its effect on plasma satiety factors (leptin, ghrelin, and apolipoprotein (apo)-AIV) is controversial. The aim of this work was to analyze these parameters before and at different times after surgery.
Plasma was obtained from 34 patients before undergoing Roux-en-Y gastric bypass and during weight loss in the 12 months following surgery.
Morbidly obese patients had significantly higher values (147%) of leptin than normal-weight (NW) persons, while their ghrelin levels were 46% less than NW. Apo-AIV levels had approximately the same value in both groups (obese and NW). During weight loss, leptin decreased by 75% and ghrelin increased by 78%. Both parameters reached values less than or near NW, respectively, at 1 year after surgery. During the first month after surgery, apo-AIV plasma levels decreased (47%) but later increased and finally returned to preoperative values. Apo-AIV levels were correlated negatively with leptin and positively with ghrelin. High-density lipoprotein (HDL) levels were positively correlated with those of ghrelin and apo-AIV.
During weight loss, plasma leptin and ghrelin could be good markers of total fat decrease. Ghrelin could also indicate gastric mucous improvement, whereas apo-AIV could indicate the recovery of intestinal function. Changes produced in the HDL levels of morbidly obese patients during weight loss suggest a decreased risk of coronary disease.
KeywordsBariatric surgery RYGBP HOMA-IR HDL Satiety
homeostasis model assessment of insulin resistance
nonesterified fatty acid
This research was funded by the Fondo de Investigaciones Sanitarias del Instituto de Salud Carlos III of the Ministerio de Sanidad y Consumo (PI030042, PI030024, and PI0700079). Both R. Llamas and E. Pardina were awarded grants from this institution.
English grammar and language have been corrected by American Journal Experts (https://doi.org/www.journalexperts.com).
Conflict of Interest
The authors declare that no conflict of interest exists.
- 28.Lohman TG, Roche AF, Martorell R, editors. Standardization of anthropometric measurements: The Airlie (VA) Consensus Conference. Champaign: Human Kinetics; 1988. p. 20–37.Google Scholar
- 33.López Tejero MD, Través Polo MC. Diagnostic method of human intestinal atrophy in a given patient of any age. 2002, PCT patent (año 2003), reference: P200201609; registre: exp. 32333. UBAR-Universitat de Barcelona, Centro de Patentes de la Universidad de Barcelona.Google Scholar
- 45.Kotidis EV, Koliakos G, Papavramidis TS, et al. The effect of biliopancreatic diversion with pylorus-preserving sleeve gastrectomy and duodenal switch on fasting serum ghrelin, leptin and adiponectin levels: is there a hormonal contribution to the weight-reducing effect of this procedure? Obes Surg 2006;16:554–9.CrossRefGoogle Scholar