Evidence-based Review of the Bioenterics Intragastric Balloon for Weight Loss
- 757 Downloads
We reviewed clinical studies performed with the Bioenterics intragastric balloon (BIB) to promote weight loss. Thirty studies were included [18 prospective (5 randomized), 12 retrospective], totaling 4,877 patients. Only one of three sham-controlled trials found a significantly higher weight loss with the BIB vs the sham procedure plus exhaustive follow-up. In nonrandomized studies, weight loss with the BIB averaged 17.8 kg (range, 4.9–28.5), corresponding to BMI changes of 4.0–9.0 kg/m2. Comorbidities resolved or improved in 52–100% of patients. Best short-term results were observed in patients devoid of binge eating disorder with a BMI in the 30.0–40.0 kg/m2 range; the BIB also helped to prepare superobese patients for bariatric surgery. Severe complications were exceptional (gastric perforation and intestinal obstruction; 0.2% each); digestive intolerance prompted early BIB removal in 2.5% of patients. Long-term (≥2 years) results are awaited, as well as well-designed studies to define the best indications for this therapy.
KeywordsObesity Gastrointestinal endoscopy Gastric balloon Weight loss
body mass index
Bioenterics intragastric balloon
- 35.National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. The evidence report. National Institutes of Health. 1998;6 Suppl 2:51S–209S.Google Scholar
- 36.Machytka E, Klvana P, Hanuskova L, Janik I. Use of pharmacotherapy for long-term maintenance of weight loss following explantation of intragastric balloon (BIB). Gut. 2007;57:A290.Google Scholar