Obesity Surgery

, Volume 19, Issue 1, pp 29–35

Ghrelin and Obestatin Levels in Severely Obese Women Before and After Weight Loss After Roux-en-Y Gastric Bypass Surgery

  • Christian L. Roth
  • Thomas Reinehr
  • Gerit-Holger Schernthaner
  • Hans-Peter Kopp
  • Stefan Kriwanek
  • Guntram Schernthaner
Research Article

Abstract

Background

Ghrelin and obestatin are derived from the same gene but have different effects: Ghrelin stimulates appetite, and previous—albeit inconsistent—data show that obestatin may be involved in satiety. The present study was designed to test the hypothesis that Roux-en-Y gastric bypass (RYGB) surgery and/or the weight loss that reliably results from this procedure would alter levels of ghrelin and obestatin and ghrelin/obestatin ratios in a cohort of morbidly obese women.

Methods

This is a longitudinal follow-up study in 18 morbidly obese women (mean weight 131.2 kg, mean body mass index [BMI] 47.4). Clinical parameters and fasting serum concentrations of ghrelin, obestatin, triglycerides, low-density lipoprotein cholesterol, glucose, and insulin were measured before and 2 years after RYGB surgery, which was associated with body weight reductions of 41.5 ± 11.6 kg (mean 62.5% excess weight loss).

Results

Ghrelin concentrations (−12%, p = 0.022) and ghrelin/obestatin ratios (−14%, p = 0.017) were lower after surgery than before, while obestatin levels did not change. Changes in ghrelin concentrations correlated with changes in insulin levels (r = 0.45, p = 0.011). Most cardiovascular risk factors studied improved postsurgically (p < 0.01).

Conclusion

In contrast to previous weight loss studies involving gastric banding, ghrelin levels decreased and obestatin levels remained stable after massive weight loss in long-term follow-up. The favorable gastrointestinal hormone profiles observed are likely to contribute to the long-term weight loss success rate attributed to RYGB.

Keywords

Ghrelin Obestatin Gastric bypass Cardiovascular risk factors Obesity Weight loss Roux-en Y gastric bypass 

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Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • Christian L. Roth
    • 1
  • Thomas Reinehr
    • 2
  • Gerit-Holger Schernthaner
    • 3
  • Hans-Peter Kopp
    • 4
  • Stefan Kriwanek
    • 5
  • Guntram Schernthaner
    • 4
  1. 1.Seattle Children’s Hospital Research InstituteSeattleUSA
  2. 2.Vestische Hospital for Children and Adolescents DattelnUniversity of Witten/HerdeckeWittenGermany
  3. 3.Department of Medicine II, Division of AngiologyMedical University of ViennaViennaAustria
  4. 4.Department of Medicine IRudolfstiftung Hospital ViennaViennaAustria
  5. 5.Department of SurgeryRudolfstiftung Hospital ViennaViennaAustria

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