Safety and Effectiveness of the Intragastric Balloon for Obesity. A Meta-Analysis
- 1.3k Downloads
Intragastric balloons have been used since 1985 to treat obesity, but an evidence-based systematic review had not been previously performed. The objective of this study is to determine the safety, efficacy, and effectiveness of the most widely used balloon, BioEnterics Intragastric Balloon (BIB®), to treat obesity.
Systematic literature review of Medline, Embase, and other information sources from inception to March 2006. The quality of selected studies was assessed. Meta-analysis of weighted mean difference was made using the inverse variance method.
We pooled 15 articles (3,608 patients) to estimate BIBs® effectiveness. The estimates for weight lost at balloon removal for BIB® were the following: 14.7 kg, 12.2% of initial weight, 5.7 kg/m2, and 32.1% of excess weight. However, data were scant after balloon removal. Yet, efficacy at balloon removal was estimated with a meta-analysis of two randomized controlled trials (75 patients) that compared balloon versus placebo, indicating the balloon group lost more weight than the placebo group. These differences in weight lost were 6.7 kg, 1.5% of initial weight, 3.2 kg/m2, and 17.6% of excess weight. Regarding BIB® safety, the majority of complications were mild and the early removal rate was 4.2%.
The use of the BIB®, within a multidisciplinary weight management program, is a short-term effective treatment to lose weight, but it is not yet possible to verify its capacity to maintain the weight lost over a long period of time.
KeywordsIntragastric balloon BIB Obesity Meta-analysis Systematic review
We thank David Peck for his structural review of this manuscript.
- 1.Fernandes M, Atallah AN, Soares BGO, et al. Baloes Intragástricos para pessoas com obesidade. Cochrane Library. Oxford: Update Software Ltd.; 2006.Google Scholar
- 2.National Institutes of Health, National Heart Lung and Blood Institute, North American Association for the Study of Obesity. Practical Guide to the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults. NIH Publication no. 00-4084. Bethesda: NIH; 2000. p. 94.Google Scholar
- 5.Allison C. Intragastric balloons: a temporary treatment for obesity. Issues in emerging health technologies, no. 79. Canadian Coordinating Office for Health Technology Assessment, Ottawa; 2006.Google Scholar
- 7.Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions. 4.2.6. In: The Cochrane Library. Issue 4, ed. Chichester, UK: John Wiley and Sons, Ltd.; 2006.Google Scholar
- 9.Khan KS, Riet G, Glanville J, et al. Undertaking systematic reviews of research on effectiveness. CRD’s guidance for those carrying out or commissioning reviews. no. 4. York: NHS Center for Reviews and Dissemination, University of York; 2001.Google Scholar
- 10.Oxford Centre for Evidence-based Medicine. Quality filters [On line]. Web of the centre for evidence-based medicine, 23-10-2006. http://www.cebm.net/levels_of_evidence.asp.
- 11.Schwartz D. Métodos estadísticos para médicos y biólogos. Barcelona: Editorial Herder; 1991. p. 385.Google Scholar
- 21.Rydzewska G, Milewski J. Balony dozoladkowe-nowa nadzieja w leczeniu otylosci? Pol Merkuriusz Lek. 2004;17 Suppl 1:114–6.Google Scholar
- 34.Sánchez B, Espinós J, Turró J, et al. Tratamiento y seguimiento nutricional en pacientes con balón intragástrico. Revista Española de Nutrición Comunitaria. 2005;11:152–5.Google Scholar