Obesity Surgery

, Volume 17, Issue 9, pp 1242–1247 | Cite as

Behavior of insulin sensitivity and its relation to leptin and tumor necrosis factor-alpha in obese women undergoing liposuction: 6-month follow-up

  • José Antonio Robles-Cervantes
  • Esperanza Martínez-Abundis
  • Manuel González-Ortiz
  • Lázaro Cárdenas-Camarena
  • Eduardo Hernández-Salazar
  • Rafael Olvera-Ozuna
Research Articles

Abstract

Background: Metabolic syndrome is a group of pathological processes which involve insulin resistance, a biochemical and molecular disorder. Obesity appears to be the most frequent clinical component in metabolic syndrome. Subcutaneous fat, independent from visceral fat, is still controversial as a marker of the pathophysiology of insulin resistance.

Methods: An open parallel-group clinical trial was performed of 12 women (age 30–40 years), with BMI from 30–33 kg/m2 and fasting glucose ≤110 mg/dl. 6 women were included in the “liposuction plus diet” group, and 6 were included in the “diet-only” group. Metabolic profile, including insulin tolerance test (ITT), leptin and tumor necrosis factor alpha (TNFα), was performed at baseline, 1 and 6 months in both groups. Subcutaneous and visceral fat was quantified with spiral tomography at baseline and after 6 months. Friedman and Wilcoxon test were used for intra-group differences, Mann-Whitney U for differences between groups, and Spearman test for correlation, with significance set atP<0.05.

Results: No difference existed between groups regarding clinical characteristics and metabolic profile. In the liposuction group, the increase in insulin sensitivity was (3.8±0.86, 3.1±0.85, 4.5±1.02 %/min,P=0.08. Insulin sensitivity did not correlate with subcutaneous fat, leptin, or TNFα. Leptin diminished at 1 month (52.7±6.04 vs 31.6±11.9),P=0.028, and correlated with the subcutaneous fat (r=0.957). In the diet-only group, TNFα diminished at 6 months,P=0.046.

Conclusion: Subcutaneous abdominal fat correlates with leptin; nevertheless, it is a weak marker for TNFα and insulin sensitivity.

Key words

Obesity liposuction insulin resistance subcutaneous fat leptin tumor necrosis factor alpha 

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Copyright information

© Springer 2007

Authors and Affiliations

  • José Antonio Robles-Cervantes
    • 1
    • 2
  • Esperanza Martínez-Abundis
    • 1
  • Manuel González-Ortiz
    • 1
  • Lázaro Cárdenas-Camarena
    • 2
  • Eduardo Hernández-Salazar
    • 1
  • Rafael Olvera-Ozuna
    • 3
  1. 1.Medical Research Unit in Clinical Epidemiology, Medical Unit of High SpecialityMexican Institute of Social SecurityGuadalajaraMexico
  2. 2.Reconstructive Surgery InstituteHealth MinistryGuadalajaraMexico
  3. 3.Radio Imagen de OccidenteGuadalajaraMexico

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