Obesity Surgery

, Volume 17, Issue 8, pp 1069–1074 | Cite as

Short-term Effects of Sleeve Gastrectomy on Type 2 Diabetes Mellitus in Severely Obese Subjects

  • J. VidalEmail author
  • A. Ibarzabal
  • J. Nicolau
  • M. Vidov
  • S. Delgado
  • G. Martinez
  • J. Balust
  • R. Morinigo
  • A. Lacy
Research Articles


Data on the effectiveness of sleeve gastrectomy (SG) in improving or resolving type 2 diabetes mellitus (T2DM) are scarce.


A 4-month prospective study was conducted on the changes in glucose homeostasis in 35 severely obese T2DM subjects undergoing laparoscopic SG (LSG) and 50 subjects undergoing laparoscopic Roux-en-Y gastric bypass (LRYGBP), matched for DM duration, type of DM treatment, and glycemic control.


At 4-months after surgery, LSG and LRYGBP operated subjects lost a similar amount of weight (respectively, 20.6 ± 0.7% and 21.0 ± 0.6%). T2DM had resolved respectively in 51.4% and 62.0% of the LSG and LRYGBP operated subjects (P = 0.332). A shorter preoperative DM duration (P < 0.05), a preoperative DM treatment not including pharmacological agents, and a better pre-surgical fasting plasma glucose (P < 0.01) or HbA1c (P < 0.01), were significantly associated with a better type 2 DM outcome in both surgical groups.


Our data show that LSG and LRYGBP result in a similar rate of type 2 DM resolution at 4-months after surgery. Moreover, our data suggest that mechanisms beyond weight loss may be implicated in DM resolution following LSG and LRYGBP.

Key words

Morbid obesity type 2 diabetes mellitus sleeve gastrectomy gastric bypass insulin sensitivity weight loss 


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Copyright information

© Springer Science + Business Media B.V. 2007

Authors and Affiliations

  • J. Vidal
    • 1
    • 2
    Email author
  • A. Ibarzabal
    • 1
  • J. Nicolau
    • 1
  • M. Vidov
    • 1
  • S. Delgado
    • 1
  • G. Martinez
    • 1
  • J. Balust
    • 1
  • R. Morinigo
    • 1
  • A. Lacy
    • 1
  1. 1.Obesity UnitHospital Clinic UniversitariBarcelonaSpain
  2. 2.Obesity UnitHospital Clínic UniversitariBarcelonaSpain

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