Obesity Surgery

, 17:649 | Cite as

Intragastric Balloon-Induced Satiety is Not Mediated by Modification in Fasting or Postprandial Plasma Ghrelin Levels in Morbid Obesity

  • Maria Asuncion Martinez-Brocca
  • Ovidio Belda
  • Juana Parejo
  • Luis Jimenez
  • Agustin del Valle
  • Jose Luis Pereira
  • Felipe Garcia-Pesquera
  • Ricardo Astorga
  • Alfonso Leal-Cerro
  • Pedro Pablo Garcia-Luna
Article

Background

The BioEnterics Intragastric Balloon (BIB) has been proposed as an adjuvant therapy for the short-term treatment of obesity. The temporal pattern of BIB-induced satiety and whether this effect is mediated by modification of ghrelin levels is unknown.

Methods

Patients with treatment-resistant morbid obesity were invited to participate in a randomized, double-blind, sham-controlled trial of 4-month duration. Anthropometric and biochemical parameters, estimation of energy intake, and pre- and postprandial evaluation of satiety were required monthly. Ghrelin response after a standard mixed meal was scheduled prior to and 4 weeks after the endoscopic procedure.

Results

21 out of 22 enrolled patients completed the study (17 women, 5 men; 35.9 ±–.9 years; BMI 50.4 ±–.8 kg/m2). Pre-intervention weight decreased from 143.8 ±–1.2 kg to 131.1 ±–2.6 kg in Group Balloon (P–lt;–.001) and from 138.8 ±–4.5 kg to 129.9 ±–5.6 kg in Group Sham (P–lt;–.01) at the end of the study. Weight loss was not significantly different in Group Balloon and Group Sham at any time-point of the follow-up. Only patients from Group Balloon showed a temporary increased pre- and postprandial satiety, which was maximal at 4 weeks after the intervention. Total area under the curve, fasting and postprandial plasma ghrelin were not significantly different between groups at inclusion or 4 weeks after follow-up. No correlation was found between any of the satiety scores at any time-point with their comparable ghrelin levels.

Conclusion

BIB induces a temporary sense of satiety in morbidly obese patients which is not mediated by modification of fasting or postprandial levels of plasma ghrelin.

Key words

Morbid obesity intragastric balloon satiety ghrelin bariatric surgery 

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Copyright information

© Springer Science + Business Media B.V. 2007

Authors and Affiliations

  • Maria Asuncion Martinez-Brocca
    • 1
  • Ovidio Belda
    • 2
  • Juana Parejo
    • 1
  • Luis Jimenez
    • 3
  • Agustin del Valle
    • 4
  • Jose Luis Pereira
    • 1
  • Felipe Garcia-Pesquera
    • 5
  • Ricardo Astorga
    • 1
  • Alfonso Leal-Cerro
    • 1
  • Pedro Pablo Garcia-Luna
    • 1
    • 6
  1. 1.Department of Endocrinology and NutritionUniversity Hospital Virgen del RocioSevilleSpain
  2. 2.Department of GastroenterologyUniversity Hospital Virgen del RocioSevilleSpain
  3. 3.Department of Clinical BiochemistryUniversity Hospital Virgen del RocioSevilleSpain
  4. 4.Section of Endocrine Surgery, Department of SurgeryUniversity Hospital Virgen del RocioSevilleSpain
  5. 5.Department of Nuclear MedicineUniversity Hospital Virgen del RocioSevilleSpain
  6. 6.Section of Clinical Nutrition. Department of Endocrinology and NutritionHospital Universitario Virgen del RocioSevilleSpain

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