Obesity Surgery

, 17:478

Relationship between Obstructive Sleep Apnea and Liver Abnormalities in Morbidly Obese Patients: A Prospective Study

  • Pauline Jouët
  • Jean-Marc Sabaté
  • Dominique Maillard
  • Simon Msika
  • Charlotte Mechler
  • Séverine Ledoux
  • Florence Harnois
  • Benoit Coffin
Article

DOI: 10.1007/s11695-007-9085-3

Cite this article as:
Jouët, P., Sabaté, JM., Maillard, D. et al. OBES SURG (2007) 17: 478. doi:10.1007/s11695-007-9085-3

Background

Morbid obesity is a risk factor of nonalcoholic steatohepatitis (NASH). Obstructive sleep apnea (OSA) could also be an independent risk factor for elevated liver enzymes and NASH. The relationships between liver injuries and OSA in morbidly obese patients requiring bariatric surgery were studied prospectively.

Methods

Every consecutive morbidly obese patient (BMI ≥40 kg/m2 or ≥35 kg/m2 with severe comorbidities) requiring bariatric surgery was included between January 2003 and October 2004. Polygraphic recording, serum aminotransferases (ALT, AST), γ-glutamyltransferase (GGT) and liver biopsy were systematically performed. OSA was present when the apnea–hypopnea index (AHI) was >10/h.

Results

62 patients (54 F; age 38.5 ±–1.0 (SD) yrs; BMI 47.8 ±–.4 kg/m2) were included. Liver enzymes (AST, ALT or GGT) were increased in 46.6%. NASH was present in 34.4% and OSA in 84.7%. Patients with OSA were significantly older (P––.015) and had a higher BMI (P––.003). In multivariate analysis, risk factors for elevated liver enzymes were the presence of OSA and male sex.The presence of NASH was similar in patients with or without OSA (32.7% vs 44.4% of patients, P––.76).

Conclusion

In this cohort of morbidly obese patients requiring bariatric surgery, one-third of patients had NASH, a prevalence similar to previous studies. OSA was found to be a risk factor for elevated liver enzymes but not for NASH.

Key words

Non-alcoholic steatohepatitis steatosis morbid obesity surgery 

Abbreviations

BMI

Body Mass Index

OSA

Obstructive Sleep Apnea

NASH

Non-Alcoholic SteatoHepatitis

AHI

Apnea–Hypopnea Index

WHR

Waist-to-Hip Ratio

ALT

alanine aminotransferase activity

AST

aspartate aminotransferase activity

GGT

gamma glutamyltransferase

Copyright information

© Springer Science + Business Media B.V. 2007

Authors and Affiliations

  • Pauline Jouët
    • 1
  • Jean-Marc Sabaté
    • 1
  • Dominique Maillard
    • 2
  • Simon Msika
    • 3
  • Charlotte Mechler
    • 4
  • Séverine Ledoux
    • 2
  • Florence Harnois
    • 1
  • Benoit Coffin
    • 1
  1. 1.Service d’Hépato-GastroentérologieAssistance Publique - Hôpitaux de Paris (APHP) Hôpital Louis MourierColombes CedexFrance
  2. 2.Service des Explorations FonctionnellesAP-HP Hôpital Louis MourierColombesFrance
  3. 3.Service de Chirurgie viscéraleAP-HP Hôpital Louis MourierColombesFrance
  4. 4.Service d’Anatomo-PathologieAP-HP Hôpital Louis MourierColombesFrance

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