Obesity Surgery

, Volume 17, Issue 3, pp 361–364 | Cite as

Dehydroepiandrosterone Behavior and Lipid Profile in Non-Obese Women undergoing Abdominoplasty

  • José Antonio Robles-Cervantes
  • Manuel Espaillat-Pavonessa
  • Lázaro Cárdenas-Camarena
  • Esperanza Martínez-Abundis
  • Manuel González-Ortiz


The aim of this study was to determine any change in dehydroepiandrosterone (DHEA) and lipid profile in non-obese women after abdominoplasty.


An auto-controlled clinical trial was carried out. 9 women aged 35 to 40 years with BMI 22–25 kg/m2 were studied. Basal lipid profile and DHEA were performed and repeated 1 month postoperatively. Statistical analysis used Wilcoxon signed-ranks test (two-tailed).


Weight of resected specimen was 606.11 ± 143.4 grams. No significant changes were observed in high-density cholesterol (48.0 ± 9.6 vs 48.8 ± 11.0 mg/dl; P = 0.106) or in triglycerides (119.2 ± 50.9 vs 148.4 ± 45.8 mg/dl; P = 0.139). Significant increases were obtained in DHEA (3.69 ± 3.05 vs 11.09 ± 6.3 ng/ml; P < 0.008), low-density cholesterol (LDL) (87.4 ± 23.5 vs 108.5 ± 28.3 mg/dl; P < 0.008 and total cholesterol (155.1 ± 30.6 vs 186.6 ± 33.1 mg/dl; P < 0.008).


Excision of subcutaneous abdominal fat in studies 1 month later increased DHEA, whose role is controversial in visceral fat distribution, and increased LDL cholesterol and total cholesterol, both risk markers for cardiovascular illness.

Key words

Dehydroepiandrosterone abdominoplasty risk markers cardiovascular disease 


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  1. 1.
    Matarasso A, Swift RW, Rankin M. Abdominoplasty and abdominal contour surgery: a national plastic sur-gery survey. Plast Reconstr Surg 2006; 117: 1797–808.PubMedCrossRefGoogle Scholar
  2. 2.
    Weber RV, Buckley MC, Fried SK et al. Subcutaneous lipectomy causes a metabolic syndrome in hamsters. Am J Physiol Regul Integr Comp Physiol 2000; 279: R936–43.PubMedGoogle Scholar
  3. 3.
    Liszka TG, Dellon AL, Im M et al. Effect of lipectomy on growth and development of hyperinsulinemia and hyperlipidemia in the Zucker rat. Plast Reconstr Surg 1998; 102: 1122–7.PubMedCrossRefGoogle Scholar
  4. 4.
    González-Ortiz M, Robles-Cervantes JA, Cárdenas-Camarena L et al. The effects of surgically removing subcutaneous fat on the metabolic profile and insulin sensitivity in obese women after large-volume liposuction treatment. Horm Metab Res 2002; 34: 446–9.PubMedCrossRefGoogle Scholar
  5. 5.
    Giugliano G, Nocoletti G, Grella E et al. Effect of liposuction on insulin resistance and vascular inflammatory markers in obese women. Br J Plast Surg 2004; 57: 190–4.PubMedCrossRefGoogle Scholar
  6. 6.
    Rizzo MR, Paolisso G, Grella R et al. Is dermolipectomy effective in improving insulin action and lowering inflammatory markers in obese women? Clin Endocrinol 2005; 63: 253–8.CrossRefGoogle Scholar
  7. 7.
    Klein S, Fontana L, Young VL et al. Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. N Engl J Med 2004; 17(350): 2549–57.CrossRefGoogle Scholar
  8. 8.
    Giese SY, Bulan EJ, Commons GW et al. Improvements in cardiovascular risk profile with large-volume liposuction: a pilot study. Plast Reconstr Surg 2001; 108: 510–9.PubMedCrossRefGoogle Scholar
  9. 9.
    Belanger C, Hould FS, Lebel S et al. Omental and subcutaneous adipose tissue steroid levels in obese men. Steroids 2006; 71: 674–82.PubMedCrossRefGoogle Scholar
  10. 10.
    McIntosh MK, Lea-Currie YR, Geigerman C et al. Dehydroepiandrosterone alters the growth of stromal vascular cells from human adipose tissue. Int J Obes 1999; 23: 595–602.CrossRefGoogle Scholar
  11. 11.
    Kochan Z, Karbowska J. Dehydroepiandrosterone upregulates resistin gene expression in white adipose tissue. Mol Cell Endocrinol 2004; 218: 57–64.PubMedCrossRefGoogle Scholar
  12. 12.
    Karbowska J, Kochan Z. Effect of DHEA on endocrine functions of adipose tissue, the involvement of PPAR gamma. Biochem Pharmacol 2005; 70: 249–57.PubMedCrossRefGoogle Scholar
  13. 13.
    Perrini S, Natalicchio A, Laviola L et al. Dehydroepiandrosterone stimulates glucose uptake in human and murine adipocytes by inducing GLUT 1 and GLUT 4 translocation to the plasma membrane. Diabetes 2004; 53: 41–52.PubMedCrossRefGoogle Scholar
  14. 14.
    Villarreal DT, John OH. Effect of DHEA on abdominal fat and insulin action in elderly women and men. JAMA 2004; 18: 2243–48.CrossRefGoogle Scholar
  15. 15.
    Diamond P, Cusan L, Gómez JL et al. Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women. J Endocrinol 1996; 150: S43–S50.PubMedCrossRefGoogle Scholar
  16. 16.
    De Pergola G, Triggiani V, Giorgino F et al. The free testosterone to dehydroepiandrosterone sulphate molar ratio as a marker of visceral fat accumulation in premenopausal obese women. Int J Obes 1994; 18: 659–64.Google Scholar
  17. 17.
    Mentz HA. Changes in diet, excercise, weight, and serum lipids following liposuction. Semin Plastic Surg 2002; 16: 183–5.CrossRefGoogle Scholar
  18. 18.
    Robles-Cervantes JA, Yáñez-Díaz S, Cárdenas-Camarena L. Modification of insulin, glucose and cholesterol levels in nonobese women undergoing liposuction: is liposuction metabolically safe? Ann Plast Surg 2004; 52: 64–7.PubMedCrossRefGoogle Scholar
  19. 19.
    Cazes L, Deitel M, Levine RH. Effect of abdominal lipectomy on lipid profile, glucose handling and blood-pressure in patients with truncal obesity. Obes Surg 1996; 6: 159–66.PubMedCrossRefGoogle Scholar
  20. 20.
    Hong YG, Kim HT, Seo SW et al. Impact of largevolume liposuction on serum lipids in orientals: a pilot study. Aesthetic Plast Surg 2006; 30: 327–32.PubMedCrossRefGoogle Scholar
  21. 21.
    Adami HO, Axelsson O, Carlstrom K et al. Serum levels of cortisol dehydroepiandrosterone, dehydroepiandrosterone sulphate, estrone and prolactin after surgical trauma in postmenopausal women. Ups J Med Sci 1982; 87: 201–13.PubMedCrossRefGoogle Scholar
  22. 22.
    Lindh A, Carlstrom K, Eklund J et al. Serum steroids and prolactin during and after major surgical trauma. Acta Anaesthesiol Scand 1992; 36: 119–24.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science + Business Media B.V. 2007

Authors and Affiliations

  • José Antonio Robles-Cervantes
    • 1
    • 2
    • 3
  • Manuel Espaillat-Pavonessa
    • 2
  • Lázaro Cárdenas-Camarena
    • 2
  • Esperanza Martínez-Abundis
    • 1
  • Manuel González-Ortiz
    • 1
  1. 1.Medical Research Unit in Clinical Epidemiology, Medical Unit of High SpecialtyMexican Institute of Social SecurityGuadalajaraMexico
  2. 2.Reconstructive Surgery Institute, Health MinistryGuadalajaraMexico
  3. 3.GuadalajaraMexico

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