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Optimization of ultrasound-assisted extraction of total phenolic contents and antioxidant activity using response surface methodology from jujube leaves (Ziziphus jujuba) and evaluation of anticholinesterase inhibitory activity

  • Salima Zemouri-Alioui
  • Mostapha Bachir bey
  • Belma Zengin Kurt
  • Fatih Sonmez
  • Hayette Louaileche
Original Paper
  • 27 Downloads

Abstract

An ultrasound-assisted procedure for the extraction of phenolics (TPC) and antioxidant activity (AA) from jujube leaves have been investigated using response surface methodology (RSM). The Box–Behnken design was used to investigate the effects of three independent variables, solvent concentration (methanol/water; 40–100%), ultrasound-intensity (20–100%), and extraction time (3–15 min) on the responses. The optimal extraction conditions were 64.20% methanol, 73.60% ultrasound intensity, and 13.27 min. Under optimal conditions, the corresponding experimental values for TPC and AA were 6098.14 mg GAE/100 g DM and 4010.63 mg AAE/100 g DM. The experimental values were in close agreement with those predicted values within a 99% confidence level, thus indicating the suitability of the model and the success of RSM in optimizing the ultrasound assisted extraction of TPC and AA of jujube leaves. The results showed that optimized jujube leaves extract exhibited inhibitory effects on both acetylcholinesterase and butyrylcholinesterase with IC50 of 62.30 ± 2.54 and 147.00 ± 2.31 µg/mL, respectively.

Keywords

Jujube leaves Ultrasound-assisted extraction Response surface methodology Phenolic contents Antioxidant activity Anticholinesterase inhibitory activity 

Notes

Acknowledgements

The authors are grateful to the Algerian Ministry of Higher Education and Scientific Research for the financial support.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la VieUniversité de BejaiaBejaiaAlgeria
  2. 2.Faculty of Pharmacy, Department of Analytical and Medicinal ChemistryBezmialem Vakif UniversityIstanbulTurkey
  3. 3.Pamukova Vocational High SchoolSakarya UniversitySakarayaTurkey

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