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Evolutionary Biology

, Volume 38, Issue 1, pp 52–67 | Cite as

Sexual Dimorphism Increases Evolvability in a Genetic Regulatory Network

  • Janna L. FierstEmail author
Research Article

Abstract

The majority of work on genetic regulatory networks has focused on environmental and mutational robustness, and much less attention has been paid to the conditions under which a network may produce an evolvable phenotype. Sexually dimorphic characters often show rapid rates of change over short evolutionary time scales and while this is thought to be due to the strength of sexual selection acting on the trait, a dimorphic character with an underlying pleiotropic architecture may also influence the evolution of the regulatory network that controls the character and affect evolvability. As evolvability indicates a capacity for phenotypic change and mutational robustness refers to a capacity for phenotypic stasis, increases in evolvability may show a negative relationship with mutational robustness. I tested this with a computational model of a genetic regulatory network and found that, contrary to expectation, sexually dimorphic characters exhibited both higher mutational robustness and higher evolvability. Decomposition of the results revealed that linkage disequilibrium within sex and linkage disequilibrium between sexes, two of the three primary components of additive genetic variance and evolvability in quantitative genetics models, contributed to the differences in evolvability between sexually dimorphic and monomorphic populations. These results indicate that producing two pleiotropically linked characters did not constrain either the production of a robust phenotype or adaptive potential. Instead, the genetic system evolved to maximize both quantities.

Keywords

Genetic regulatory network Mutational robustness Dimorphic trait Epistasis Pleiotropy Linkage disequilibrium 

Notes

Acknowledgments

I would like to thank both my advisors, Thomas F. Hansen and David Houle, for helpful discussions during the development of this research. The manuscript, particularly the figures, benefited from comments from Jason Pienaar and two anonymous reviewers provided insightful suggestions. I would also like to thank the Center for Ecological and Evolutionary Synthesis at the University of Oslo for hosting my research visit. This work was supported by a Norwegian Research Council Leiv Eiriksson Mobility Grant, and a U.S. National Science Foundation Biological Informatics Postdoctoral Fellowship.

Supplementary material

11692_2010_9103_MOESM1_ESM.pdf (157 kb)
PDF (156 KB)

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Biological ScienceKing Life Sciences Building, Florida State UniversityTallahasseeUSA
  2. 2.Center for Ecology and Evolutionary BiologyUniversity of OregonEugeneUSA

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