Obésité

, Volume 6, Issue 2, pp 136–136

La surexpression du gène FTO chez la souris entraîne une augmentation de la prise alimentaire et le développement d’une obésité

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Références

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    Church C (2010) Overexpression of FTO leads to increased food intake and results in obesity. Nature Genetics (2010). Published online 14 november 2010Google Scholar
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    Scuteri A (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 3, e115PubMedCrossRefGoogle Scholar
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    Cecil JE (2008) An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 359:2558–2566PubMedCrossRefGoogle Scholar
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    Fischer J (2009) Inactivation of the FTO gene protects from obesity. Nature 458:894–898PubMedCrossRefGoogle Scholar
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    Tung YC (2010) Hypothalamic-specific manipulation of FTO, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS ONE 5, e8771PubMedCrossRefGoogle Scholar
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    Berulava T, Horsthemke B (2010) The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels. Eur J Hum Genet 18:1054–1056PubMedCrossRefGoogle Scholar

Copyright information

© Springer Paris 2011

Authors and Affiliations

  1. 1.Institut Cochin« Expression génique, développement et maladies » (EGDM), Equipe 26/Inserm U1016/CNRS UMR 8104/Université Paris-DescartesParisFrance

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