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Obésité

, Volume 2, Issue 4, pp 331–338 | Cite as

Obésité sarcopénique: « parle à mon gras, mon muscle est malade »!

  • S. Walrand
  • Y. Boirie
Revue Scientifique / Scientific Review

Résumé

La réaction inflammatoire issue de l’accumulation adipeuse est l’un des mécanismes expliquant les liens forts entre l’obésité et certaines pathologies métaboliques. Du fait des modifications de la composition corporelle avec l’âge, en particulier l’augmentation de la masse adipeuse, ces phénomènes inflammatoires pourraient être néfastes pour la fonction musculaire chez la personne âgée. Les effets des cytokines pro-inflammatoires sur le métabolisme protéino-énergétique musculaire (réduction de l’insulinosensibilité, augmentation de la perte protéique) sont connus. Les adipocytokines produites en excès chez le sujet en surpoids, notamment au cours de la phase postprandiale, pourraient aussi participer au dysfonctionnement métabolique et fonctionnel musculaire avec l’âge et favoriser le développement de l’obésité sarcopénique.

Mots clés

Obésité sarcopénique Réaction inflammatoire postprandiale Adipocytokines Alimentation lipidique 

Sarcopenic obesity: “Talk to my fat, my muscle is out”!

Abstract

Inflammatory reaction caused by a fat accumulation is one of the mechanisms that explain the strong links that exist between obesity and some metabolic diseases. Because of changes in body composition with age, i.e. increase in adipose tissue; this inflammatory reaction could be harmful for muscle function in elderly people. The effects of pro-inflammatory cytokines on muscle protein and energy metabolism (reduction in insulin sensitivity, increase in protein loss) are known. Adipocytokines produced in excess in overweight subjects, especially during the postprandial period, could therefore contribute to metabolic and functional changes in muscle with age and encourage the onset of sarcopenic obesity.

Keywords

Sarcopenic obesity Postprandial inflammation Adipocytokines Lipid Food 

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Copyright information

© Springer Paris 2007

Authors and Affiliations

  1. 1.Inra, UMR 1019unité de nutrition humaineClermont-FerrandFrance
  2. 2.UMR 1019, unité de nutrition humaine, UFR de médecineUniversité de Clermont-IClermont-FerrandFrance
  3. 3.CHU de Clermont-Ferrand, service de nutrition cliniquehôpital Gabriel-MontpiedClermont-FerrandFrance
  4. 4.Laboratoire de nutrition humaineClermont-Ferrand cedex 01France

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