Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea

  • Seo Yeon Baik
  • Hyunah Kim
  • So Jung Yang
  • Tong Min Kim
  • Seung-Hwan Lee
  • Jae Hyoung Cho
  • Hyunyong Lee
  • Hyeon Woo Yim
  • Kun-Ho Yoon
  • Hun-Sung KimEmail author
Research Article


Few long-term follow-up studies have compared the changes in renal function according to the type of statin used in Korea. We compared the long-term effects of statin intensity and type on the changes in the glomerular filtration rate (GFR). We extracted data of patients who took statin for the first time. We analyzed whether or not different statins affect the changes in GFR at 3 months after baseline and 4 years after. We included 3678 patients and analyzed the changes in GFR. The GFR decreased by 3.2%±0.4% on average 4 years after the first statin prescription, indicating statistically significant deterioration (from 83.5±0.4 mL/min/1.73 m2 to 79.9 0.4 mL/min/1.73 m2, P < 0.001). When comparing the GFR among different statins, significant differences were observed between atorvastatin and fluvastatin (–5.3%±0.7% vs. 1.2%±2.2%, P < 0.05) and between atorvastatin and simvastatin (–5.3%±0.7% vs.–0.7%±0.8%, P < 0.05). In pitavastatin (odds ratio [OR]= 0.64, 95% confidence interval [CI]= 0.46–0.87, P < 0.005) and simvastatin (OR = 0.69, 95% CI = 0.53–0.91, P < 0.008), the GFR rate that decreased by < 60 mL/min/1.73 m2 was significantly lower than that of atorvastatin. Regarding long-term statin intake, GFR changed with the type of statin. This work is the first in Korea to compare each statin in terms of changes in the GFR after the statin prescription.


statin glomerular filtration rate HMG-CoA reductase inhibitor chronic kidney disease 


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This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea (No. HC15C1362).


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Copyright information

© Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Seo Yeon Baik
    • 1
  • Hyunah Kim
    • 2
  • So Jung Yang
    • 1
  • Tong Min Kim
    • 1
  • Seung-Hwan Lee
    • 3
  • Jae Hyoung Cho
    • 3
  • Hyunyong Lee
    • 4
  • Hyeon Woo Yim
    • 5
  • Kun-Ho Yoon
    • 1
    • 3
  • Hun-Sung Kim
    • 1
    • 3
    Email author
  1. 1.Department of Medical Informatics, College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea
  2. 2.College of PharmacySookmyung Women’s UniversitySeoulRepublic of Korea
  3. 3.Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea
  4. 4.Clinical Research Coordinating Center, Catholic Medical CenterThe Catholic University of KoreaSeoulRepublic of Korea
  5. 5.Department of Preventive Medicine, College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

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